ArticleJournal of clinical medicine2022
Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Subsyndromal Delirium in Elderly Critical Care Patients: A Meta-Analysis of Prevalence and Risk Factors.Geriatrics & gerontology international · 2026Pooled it
- A prospective cohort study on the incidence and influencing factors of subsyndromal delirium in ICU patients.Frontiers in psychiatry · 2026Article
- Validation of the confusion assessment method for intensive care.Open medicine (Warsaw, Poland) · 2026Article
- [Factors-related to the severity of delirium among older adults in neurologic intensive care units: A retrospective study using electronic medical record data].Journal of Korean gerontological nursing · 2025Article
- Incidence and influencing factors of subsyndromal delirium in elderly patients with pancreatic surgery: a prospective study.Frontiers in psychiatry · 2025Article
- Delirium severity in the intensive care unit.Critical care science · 2024Article
- Article
- Subsyndromal Delirium in Critically Ill Patients-Cognitive and Functional Long-Term Outcomes.Journal of clinical medicine · 2023Article
- [Postoperative Delirium in Patients on Cardiopulmonary Bypass for Cardiovascular Surgeries: Incidence and Influencing Factors].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite recent advances in the field, the association between subsyndromal delirium (SSD) in the ICU and poor outcomes is not entirely clear. We performed a retrospective multicentric observational study analyzing mental status during the first 72 h of ICU stay. Of the 681 patients included, SSD occurred in 22.7%. Considering the worst cognitive assessment during the first 72 h, 233 (34%) patients had normal mental status, 124 (18%) patients had SSD and 324 (48%) patients had delirium or coma. SSD was not independently associated with an increased risk of death when compared with normal mental status (OR 95%IC 1.0 vs. 1.35 [0.73−1.49], p = 0.340), but was associated with a longer ICU LOS (7.0 (4−12) vs. 4 (3−8) days, p < 0.001). SSD patients who deteriorated to delirium or coma (21%) had a longer ICU LOS in comparison with those who improved or maintained mental status (8 (5−11) vs. 6 (4−8) days, p = 0.025), but did not have an increase in mortality. The main factors associated with the progression from SSD to delirium or coma were the use of mechanical ventilation, the use of intravenous benzodiazepines and a baseline APACHE II score > 23 points. Our findings support the association of SSD with increased ICU LOS, but not with ICU mortality. Monitoring the trajectory of SSD early at ICU admission can help to identify patients with increased risk of conversion from SSD to delirium or coma.
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