Evidence map›Paper›PMID 36431181›Full record

ReviewJournal of clinical medicine2022

Graft Intra-Articular Remodeling and Bone Incorporation in ACL Reconstruction: The State of the Art and Clinical Implications.

Lorenzo Moretti, Davide Bizzoca, Giuseppe Danilo Cassano, Nuccio Caringella, Michelangelo Delmedico, Biagio Moretti

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lorenzo MorettiOrthopaedic and Trauma Unit, Department of Translational Biomedicine and Neuroscience "DiBraiN", University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70120 Bari, Italy.
Davide BizzocaOrthopaedic and Trauma Unit, Department of Translational Biomedicine and Neuroscience "DiBraiN", University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70120 Bari, Italy.ORCID 0000-0002-7516-2333
Giuseppe Danilo CassanoOrthopaedic and Trauma Unit, Department of Translational Biomedicine and Neuroscience "DiBraiN", University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70120 Bari, Italy.ORCID 0000-0001-9212-1253
Nuccio CaringellaOrthopaedic and Trauma Unit, Department of Translational Biomedicine and Neuroscience "DiBraiN", University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70120 Bari, Italy.
Michelangelo DelmedicoOrthopaedic and Trauma Unit, Department of Translational Biomedicine and Neuroscience "DiBraiN", University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70120 Bari, Italy.
Biagio MorettiOrthopaedic and Trauma Unit, Department of Translational Biomedicine and Neuroscience "DiBraiN", University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70120 Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The knee is one of the most frequently affected joints in sports trauma, and anterior cruciate ligament (ACL) injury and meniscal tears are the most common lesions. ACL reconstruction (ACLR) remains the treatment of choice for patients willing to return to their previous activity. There are different surgical techniques and different possible usable grafts. The graft used for ACLR surgery undergoes a bone incorporation process and an intra-articular remodelling named ligamentization until it reaches characteristics similar to the native ligament. After the first incorporation stage, the remodelling process is divided into an early stage that could last 4 weeks, a proliferative stage that lasts 4 to 12 weeks, and a final stage of ligamentization that could last over 1 year. The period of return to sport (RTS) after ACLR, which is becoming shorter and shorter, can be a high-risk period for athletes due to the risk of graft failure. This systematic review aims to define the phases of the ligamentization process considering graft type and fixation techniques, as well as the graft's anatomopathological and biomechanical characteristics, to evaluate a criterion-based rehab progression and maximize patient outcomes for an RTS respecting graft biology. The rehabilitative program has to promote and optimize the graft remodelling and incorporation processes; moreover, it has to accommodate physiological graft healing and avoid overloading. An early RTS and noncompliance with the biological characteristics of the graft in the various phases are associated with a high incidence of re-injury.

Indexed as

anterior cruciate ligamentanterior cruciate ligament reconstructiongraft healinggraft incorporationgraft ligamentizationgraft remodelingreturn to sport

Identifiers

PMID36431181
PMCPMC9693137

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.