Evidence map›Paper›PMID 36431139›Full record

ReviewJournal of clinical medicine2022

Recent Insights into Neutrophil Extracellular Traps in Cardiovascular Diseases.

Yuan Dong, Yuejie Zhang, Xuanyi Yang, Cen Yan, Yingmei Feng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  15. Neutrophil extracellular traps in acute coronary syndrome.Journal of inflammation (London, England) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yuan DongDepartment of Science and Technology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.ORCID 0000-0002-8231-2846
Yuejie ZhangDepartment of Science and Technology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Xuanyi YangDepartment of Science and Technology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Cen YanDepartment of Science and Technology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.ORCID 0000-0002-9700-6761
Yingmei FengDepartment of Science and Technology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.ORCID 0000-0001-5248-0155
Capital Medical University · CN

Funding

National Natural Science Foundation of China 81670765&82070841
6 · The paper itself

Abstract

Neutrophils are primary effector cells of the innate immune system. Emerging evidence has consistently shown that activated neutrophils produce and release neutrophil extracellular traps (NETs) that play roles in immunity and non-infectious diseases. NETs are composed of DNA and proteins and serve as a structural platform for pathogen sequestration and degradation. In contrast to their protective role during pathogenic infection, NETs are pathologically involved in cardiovascular disease (CVD). In this review, we introduce the formation, release, and clearance of NETs and the regulatory mechanisms of NETs formation, followed by an overview of the clinical evidence for the involvement of NETs in CVD. Because atherosclerosis is a fundamental part of the pathogenesis of CVD, we chose to focus on the mechanisms by which NETs promote endothelial cell damage and collaborate with macrophages and platelets to accelerate plaque progression and thrombosis. Finally, we present options for clinical intervention to inhibit NETs production and release in the treatment of CVD. In conclusion, this review integrates the latest findings and provides new insights into NETs, which represent a novel biomarker and therapeutic target in clinical practice.

Indexed as

atherosclerosiscardiovascular diseaseNETosisneutrophil extracellular trapsnon-infectious inflammation

Identifiers

PMID36431139
PMCPMC9698501
OpenAlexW4308802817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.