ArticleJournal of clinical medicine2022
Impact of COVID-19 Related Maternal Stress on Fetal Brain Development: A Multimodal MRI Study.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Promoting expertise knowledge sharing in paediatric virology: An update (Review).Experimental and therapeutic medicine · 2026Review
- Placental hypoplasia and vascular malperfusion are associated with reduced brain volumes in fetal congenital heart disease.Pediatric research · 2026Article
- Perinatal hardship and infant neurodevelopment: insights from a global pandemic.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Prenatal maternal psychological distress is associated with neurodevelopmental outcomes in toddlers with congenital heart disease.Pediatric research · 2026Article
- Maternal Socioeconomic Opportunity and Race-Ethnicity Intersect to Influence Fetal Brain Volumes in Congenital Heart Disease.Journal of the American Heart Association · 2025Article
- Advances in fetal and neonatal neuroimaging and everyday exposures.Pediatric research · 2024Review
- Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy.Molecular psychiatry · 2024Review
- Neonatal outcomes of maternal prenatal coronavirus infection.Pediatric research · 2024Review
- Brain spatial reconciliation through multisensory integration in the impact of pandemic fatigue on workplace.Frontiers in human neuroscience · 2024Article
- Developmental trajectories of the default mode, frontoparietal, and salience networks from the third trimester through the newborn period.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Mental Health Challenges during the COVID-19 Pandemic.Journal of clinical medicine · 2023Article
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8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundDisruptions in perinatal care and support due to the COVID-19 pandemic was an unprecedented but significant stressor among pregnant women. Various neurostructural differences have been re-ported among fetuses and infants born during the pandemic compared to pre-pandemic counterparts. The relationship between maternal stress due to pandemic related disruptions and fetal brain is yet unexamined.
methodsPregnant participants with healthy pregnancies were prospectively recruited in 2020-2022 in the greater Los Angeles Area. Participants completed multiple self-report assessments for experiences of pandemic related disruptions, perceived stress, and coping behaviors and underwent fetal MRI. Maternal perceived stress exposures were correlated with quantitative multimodal MRI measures of fetal brain development using multivariate models.
resultsIncreased maternal perception of pandemic related stress positively correlated with normalized fetal brainstem volume (suggesting accelerated brainstem maturation). In contrast, increased maternal perception of pandemic related stress correlated with reduced global fetal brain temporal functional variance (suggesting reduced functional connectivity).
conclusionsWe report alterations in fetal brainstem structure and global functional fetal brain activity associated with increased maternal stress due to pandemic related disruptions, suggesting altered fetal programming. Long term follow-up studies are required to better understand the sequalae of these early multi-modal brain disruptions among infants born during the COVID-19 pandemic.
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