ArticleLife (Basel, Switzerland)2022
Bioactivity Potential of Bioceramic-Based Root Canal Sealers: A Scoping Review.
Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The effect of bioceramic materials on dentin formation and their use to protect the dentin-pulp complex-a systematic review and meta-analysis.Odontology · 2026Pooled it
- Review
- Fabrication and characterization of a bioactive glass and tricalcium silicate incorporated resin-based root canal sealer.Journal of conservative dentistry and endodontics · 2026Article
- Oxidative Stress, Pro-Inflammatory Response, Cytotoxicity and Apoptosis Induced by Contemporary Endodontic Sealers in Human Periodontal Ligament Fibroblasts.Journal of functional biomaterials · 2026Article
- Bioactive Materials and Novel Techniques in Endodontics: Translational Advances for Clinical Practice.Journal of functional biomaterials · 2026Article
- Osteogenic Potential of Various Premixed Hydraulic Calcium Silicate-Based Sealers on Human Bone Marrow Stem Cells.Materials (Basel, Switzerland) · 2025Article
- Functional and Bioactive Performance of Premixed Bioceramic Sealers with Warm Obturation: A Scoping Review.Gels (Basel, Switzerland) · 2025Review
- Biocompatibility and Bioactivity Evaluation of Novel Calcium Silicate-Based Sealer: In Vitro Study on Human Dental Pulp Stem Cells.European journal of dentistry · 2025Article
- Change in serum biomarker levels in patients of apical periodontitis after root canal treatment using two different root canal sealers: A randomized controlled trial.Journal of conservative dentistry and endodontics · 2025Article
- Microstructural and elemental characterization of novel bioactive glass bioceramic sealer using Fourier transform infrared and X-ray diffraction analysis.Journal of conservative dentistry and endodontics · 2025Article
- Calcium Silicate-Based Sealers: Apatite Deposition on Root Canal Dentin and pH Variation Analysis.European journal of dentistry · 2025Article
- Effect of bioceramic sealers in enhancing root canal healing.Bioinformation · 2025Article
- Comparative Analysis of Interfacial Adaptation and Depth Penetration of Recent HiFlow versus Regular Bioceramic Sealers in Conjunction with BC Gutta-Percha Points Using Two Different Obturation Techniques-A Preliminary Report of an Ex Vivo Study.Journal of functional biomaterials · 2024Article
- Comparative bioactivity and immunomodulatory potential of the new Bioroot Flow and AH Plus Bioceramic sealer: An in vitro study on hPDLSCs.Clinical oral investigations · 2024Article
- Physicochemical properties of AH plus bioceramic sealer, Bio-C Sealer, and ADseal root canal sealer.Head & face medicine · 2024Article
- Evaluation of the apical sealing of an eggshell hydroxyapatite-based sealer.Journal of clinical and experimental dentistry · 2023Article
- Hydraulic calcium silicate-based root canal sealers mitigate proinflammatory cytokine synthesis and promote osteogenesisJournal of dental sciences · 2023Article
- Evaluation of the cytotoxicity, apoptotic effects, and remineralization potential of recent bioceramic-based root canal sealers.Journal of oral biology and craniofacial researchArticle
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBioceramic-based root canal sealers are novel materials with a bioactivity potential that stands out compared with conventional root canal sealers. However, the term bioactivity may be overused and is often misunderstood. Hence, the objective of this study was to synthesize and map key concepts related to the bioactivity analysis of bioceramic-based root canal sealers.
methodsThe present scoping review is reported in accordance with the PRISMA-ScR Statement and is registered in the Open Science Framework. Two blinded reviewers carried out a comprehensive search in six databases up to January 10th, 2022: MEDLINE, Scopus, Embase, Web of Science, Cochrane Library, and Lilacs/BBO. Eligibility was considered for in vitro and in vivo studies that evaluated the bioactivity potential of bioceramic-based root canal sealers.
resultsA total of 53 studies were included in the qualitative synthesis. In vitro bioactivity was evaluated through the mineralization potential, formation of carbonated apatite on the surface, and the gene expression related to proteins involved in the mineralization process. Meanwhile, for in vivo studies, staining techniques associated with immunohistochemical tests were mainly used to detect mineralization on the material-host tissue interface.
conclusionsAccording to the methodology used, the most prevalent methods to assess bioactivity in acellular form were the immersion of the material in Hank's balanced salt solution, followed by surface observation with scanning electron microscopy and energy dispersive X-ray. In cell cultures, the chosen method was usually Alizarin Red staining, followed by the evaluation of alkaline phosphatase enzymatic activity and the use of molecular biology tests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.