Minimal Influence of Cayenne Pepper on the Human Gastrointestinal Microbiota and Intestinal Inflammation in Healthy Adult Humans-A Pilot Study.

Sihan Bu, Wreeti Kar, Robin M Tucker, Sarah S Comstock

Open access · goldAbstract read

In one paragraph

Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 47% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Optimized framework for evaluating F3 transgressive segregants in cayenne pepper.BMC plant biology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sihan BuDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA.

Wreeti KarDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA.

Robin M TuckerDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-6838-0105

Sarah S ComstockDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0003-3107-7652

Michigan State University · US

Funding

McCormick (United States) to RMTMichigan State University start-up funds

6 · The paper itself

Abstract

Diet impacts human gut microbial composition. Phytochemicals in cayenne pepper (CP), such as capsaicin, have anti-inflammatory properties and alter bacterial growth in vitro. However, the evidence that CP impacts the human microbiota and intestinal inflammation in free-living adults is lacking. Thus, the objective of this randomized cross-over study was to determine the influence of CP on human gut microbiota and intestinal inflammation in vivo. A total of 29 participants were randomly allocated to consume two 250 mL servings of tomato juice plus 1.8 g of CP each day or juice only for 5 days before crossing over to the other study arm. Fecal samples were analyzed. CP reduced

Indexed as

BifidobacteriumcalprotectincapsaicinGp6lipocalin-2OscillibacterPhascolarctobacteriumtomato juice

Identifiers

PMID36430985

DOI10.3390/life12111849

PMCPMC9695709

OpenAlexW4309008616

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.