Evidence map›Paper›PMID 36430969›Full record

ArticleInternational journal of molecular sciences2022

Modeling RTT Syndrome by iPSC-Derived Neurons from Male and Female Patients with Heterogeneously Severe Hot-Spot MECP2 Variants.

Sara Perego, Valentina Alari, Gianluca Pietra, Andrea Lamperti, Alessandro Vimercati, Nicole Camporeale, Maria Garzo, Francesca Cogliati, Donatella Milani, Aglaia Vignoli and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Sara PeregoExperimental Research Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.ORCID 0000-0003-3096-2342
Valentina AlariExperimental Research Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.
Gianluca PietraLaboratory of Biology BIO@SNS, Scuola Normale Superiore, Piazza dei Cavalieri, 7, 56126 Pisa, Italy.
Andrea LampertiExperimental Research Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.
Alessandro VimercatiExperimental Research Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.
Nicole CamporealeExperimental Research Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.
Maria GarzoExperimental Research Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.
Francesca CogliatiExperimental Research Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.ORCID 0000-0001-6073-5445
Donatella MilaniFondazione IRCCS Ca Granda Ospedale Maggiore, Policlinico, Via Francesco Sforza, 28, 20122 Milan, Italy.ORCID 0000-0002-3087-8514
Aglaia VignoliDepartment of Health Sciences, Università degli Studi di Milano, Struttura Complessa di Neuropsichiatria dell'Infazia e Adolescenza ASST GOM Niguarda, Piazza Ospedale Maggiore, 3, 20162 Milan, Italy.ORCID 0000-0003-4638-4663
Angela PeronChild Neuropsychiatry Unit-Epilepsy Center, Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, Università Degli Studi di Milano, 20142 Milan, Italy.ORCID 0000-0002-1769-6548
Lidia LarizzaExperimental Research Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.ORCID 0000-0002-1367-7227
Tommaso PizzorussoLaboratory of Biology BIO@SNS, Scuola Normale Superiore, Piazza dei Cavalieri, 7, 56126 Pisa, Italy.
Silvia RussoExperimental Research Laboratory of Medical Cytogenetics and Molecular Genetics, IRCCS Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy.ORCID 0000-0002-5893-0193
IRCCS Istituto Auxologico Italiano · ITScuola Normale Superiore · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITOspedale San Paolo · ITUniversity of Milan · IT

Funding

AIRETT 08A_621 and 08A_801
6 · The paper itself

Abstract

Rett syndrome caused by

Indexed as

Induced Pluripotent Stem CellsRett SyndromeFemaleHumansMaleNeuronsPhenotypeearly morphological neuronal biomarkersgenotype-phenotype correlationhot-spot MECP2 pathogenic variantsiPSC-neuronsmature neuron e-recordingsRett syndromeX inactivation mosaicism

Identifiers

PMID36430969
PMCPMC9697612
OpenAlexW4309718019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.