Evidence map›Paper›PMID 36430924›Full record

ArticleInternational journal of molecular sciences2022

Hager Jaouadi, Alexis Théron, Jérôme Hourdain, Hélène Martel, Karine Nguyen, Raja Habachi, Jean-Claude Deharo, Frédéric Collart, Jean-François Avierinos, Stéphane Zaffran

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hager JaouadiMarseille Medical Genetics, INSERM, Aix Marseille Université, U1251 Marseille, France.ORCID 0000-0002-6806-0072
Alexis ThéronMarseille Medical Genetics, INSERM, Aix Marseille Université, U1251 Marseille, France.ORCID 0000-0001-9453-9039
Jérôme HourdainDepartment of Cardiology, La Timone Hospital, 13005 Marseille, France.
Hélène MartelDepartment of Cardiology, La Timone Hospital, 13005 Marseille, France.
Karine NguyenMarseille Medical Genetics, INSERM, Aix Marseille Université, U1251 Marseille, France.
Raja HabachiDepartment of Cardiology, La Timone Hospital, 13005 Marseille, France.
Jean-Claude DeharoDepartment of Cardiology, La Timone Hospital, 13005 Marseille, France.
Frédéric CollartDepartment of Cardiac Surgery, La Timone Hospital, 13005 Marseille, France.ORCID 0000-0003-4247-7184
Jean-François AvierinosMarseille Medical Genetics, INSERM, Aix Marseille Université, U1251 Marseille, France.
Stéphane ZaffranMarseille Medical Genetics, INSERM, Aix Marseille Université, U1251 Marseille, France.ORCID 0000-0002-0811-418X
Hôpital de la Timone · FRInserm · FR

Funding

French Muscular Dystrophy Association MoThARD-Project
6 · The paper itself

Abstract

Mitral valve prolapse (MVP) is a common valvular heart defect with variable outcomes. Several studies reported MVP as an underestimated cause of life-threatening arrhythmias and sudden cardiac death (SCD), mostly in young adult women. Herein, we report a clinical and genetic investigation of a family with bileaflet MVP and a history of syncopes and resuscitated sudden cardiac death. Using family based whole exome sequencing, we identified two missense variants in the

Indexed as

Mitral Valve ProlapseArrhythmias, CardiacDeath, Sudden, CardiacFemaleHumansNAV1.5 Voltage-Gated Sodium ChannelSyncopeYoung AdultNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humanfamilial mitral valve prolapsegenetic arrhythmia substrateH558R polymorphismresuscitated sudden cardiac deathSCN5A mutationsyncope

Identifiers

PMID36430924
PMCPMC9692711
OpenAlexW4309738100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.