Evidence map›Paper›PMID 36430896›Full record

ArticleInternational journal of molecular sciences2022

Effect of Bladder Injection of OnabotulinumtoxinA on the Central Expression of Genes Associated with the Control of the Lower Urinary Tract: A Study in Normal Rats.

Soultana Markopoulou, Lina Vardouli, Fotios Dimitriadis, Dimitra Psalla, Alexandros Lambropoulos, Apostolos Apostolidis

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Soultana MarkopoulouDepartment of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
Lina VardouliDepartment of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
Fotios Dimitriadis1st Department of Urology, Aristotle University of Thessaloniki, 'G. Gennimatas' General Hospital, 541 24 Thessaloniki, Greece.ORCID 0000-0003-1198-9144
Dimitra PsallaVeterinary School, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.ORCID 0000-0002-1539-4124
Alexandros Lambropoulos1st Department of Obstetrics & Gynaecology, Molecular Biology Lab, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.ORCID 0000-0002-8887-222X
Apostolos Apostolidis2nd Department of Urology, Aristotle University of Thessaloniki, 'Papageorgiou' General Hospital, Ring Road, Nea Efkarpia, 56 403 Thessaloniki, Greece.
Aristotle University of Thessaloniki · GR

Funding

European Social Fund and Greek national resources under the framework of the "ARISTEIA" project AVLOS 2130 of the "Education & Lifelong Learning" Operational Programme
6 · The paper itself

Abstract

To investigate a possible central mechanism of action of Botulinum toxin A (BoNT/A) following injection in the bladder, complementary to the acknowledged peripheral bladder effect, we studied changes in the expression of neuropeptides and receptors involved in lower urinary tract function in the spinal cord (SC) and dorsal root ganglia (DRG) of normal rats following BoNT/A bladder injection. Thirty-six Sprague-Dawley rats, divided into three groups of n = 12, received bladder injections of 2U or 5U OnabotulinumtoxinA (BOTOX

Indexed as

Botulinum Toxins, Type AAnimalsGanglia, SpinalRatsRats, Sprague-DawleySpinal CordUrinary BladderBotulinum Toxins, Type Abladdercentral nervous systemdetrusoronabotulinumtoxinAspinal cord

Identifiers

PMID36430896
PMCPMC9694129
OpenAlexW4309744284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.