Evidence map›Paper›PMID 36430824›Full record

ArticleInternational journal of molecular sciences2022

Diastereoselective Synthesis of Novel Spiro-Phosphacoumarins and Evaluation of Their Anti-Cancer Activity.

Valeriia V Sennikova, Alena V Zalaltdinova, Yulia M Sadykova, Ayrat R Khamatgalimov, Almir S Gazizov, Alexandra D Voloshina, Anna P Lyubina, Syumbelya K Amerhanova, Julia K Voronina, Elena A Chugunova and 3 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Valeriia V SennikovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str. 8, 420088 Kazan, Russia.
Alena V ZalaltdinovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str. 8, 420088 Kazan, Russia.ORCID 0000-0002-4822-7330
Yulia M SadykovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str. 8, 420088 Kazan, Russia.ORCID 0000-0003-2093-2860
Ayrat R KhamatgalimovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str. 8, 420088 Kazan, Russia.ORCID 0000-0002-2865-8619
Almir S GazizovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str. 8, 420088 Kazan, Russia.ORCID 0000-0001-9899-9606
Alexandra D VoloshinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str. 8, 420088 Kazan, Russia.ORCID 0000-0002-3540-8554
Anna P LyubinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str. 8, 420088 Kazan, Russia.
Syumbelya K AmerhanovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str. 8, 420088 Kazan, Russia.
Julia K VoroninaN.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky Ave. 31, 119991 Moscow, Russia.ORCID 0000-0001-9222-5853
Elena A ChugunovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str. 8, 420088 Kazan, Russia.ORCID 0000-0002-9371-1877
Nurbol O AppazovKorkyt Ata Kyzylorda State University, 29A Aiteke Bi St., Kyzylorda 120014, Kazakhstan.ORCID 0000-0001-8765-3386
Alexander R BurilovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str. 8, 420088 Kazan, Russia.
Michail A PudovikArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str. 8, 420088 Kazan, Russia.

Funding

FRC Kazan Scientific Center of RASKurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences
6 · The paper itself

Abstract

Herein we present the regio- and diastereoselective synthesis of novel pyrrolidine-fused spiro-dihydrophosphacoumarins via intermolecular [3 + 2] cycloaddition reaction. The presented approach is complementary to existing ones and provides an easy entry to the otherwise inaccessible derivatives. Additionally, the unprecedented pathway of the reaction of 4-hydroxycoumarin with azomethine ylides is described. The anti-cancer activity of the obtained compounds was tested in vitro, the most potent compound being 2.6-fold more active against the HuTu 80 cell line than the reference 5-fluorouracil, with a selectivity index > 32.

Indexed as

Spiro CompoundsCycloaddition ReactionStereoisomerismSpiro Compoundsanti-cancerazomethine ylidecycloadditioncytotoxicityphosphacoumarinquantum chemistry

Identifiers

PMID36430824
PMCPMC9695012

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.