Evidence map›Paper›PMID 36430814›Full record

ArticleInternational journal of molecular sciences2022

Polyglycerol Adipate-Grafted Polycaprolactone Nanoparticles as Carriers for the Antimicrobial Compound Usnic Acid.

Vincenzo Taresco, Isotta Tulini, Iolanda Francolini, Antonella Piozzi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vincenzo TarescoDepartment of Chemistry, The University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0003-4476-8233
Isotta TuliniDepartment of Chemistry, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-2633-6648
Iolanda FrancoliniDepartment of Chemistry, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-0180-2334
Antonella PiozziDepartment of Chemistry, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-4792-0520

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoparticle (NP) drug delivery systems are known to potentially enhance the efficacy of therapeutic agents. As for antimicrobial drugs, therapeutic solutions against drug-resistant microbes are urgently needed due to the worldwide antimicrobial resistance issue. Usnic acid is a widely investigated antimicrobial agent suffering from poor water solubility. In this study, polymer nanoparticles based on polyglycerol adipate (PGA) grafted with polycaprolactone (PCL) were developed as carriers for usnic acid. We demonstrated the potential of the developed systems in ensuring prolonged bactericidal activity against a model bacterial species,

Indexed as

Anti-Infective AgentsNanoparticlesAdipatesAnti-Bacterial AgentsBenzofuransGlycerolPolyestersPolymersStaphylococcus epidermidisAdipatesadipic acidAnti-Bacterial AgentsAnti-Infective AgentsBenzofuransGlycerolpolycaprolactonePolyesterspolyglycerolPolymersusnic aciddrug releasemicrobial infectionsnanoparticlespolycaprolactonepolyglycerol adipateusnic acid

Identifiers

PMID36430814
PMCPMC9693002

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.