Evidence map›Paper›PMID 36430807›Full record

ArticleInternational journal of molecular sciences2022

Mobilization of Hematopoietic Stem and Progenitor Cells during Dengue Virus Infection.

Irwin Puc, Tzu-Chuan Ho, Yu-Wen Chien, Sia-Seng Tan, Yu-Cin Fong, Yi-Ju Chen, Sheng-Hsuan Wang, Yun-Hsuan Li, Chun-Hong Chen, Po-Lin Chen and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Irwin PucInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.ORCID 0000-0002-0182-3768
Tzu-Chuan HoInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
Yu-Wen ChienDepartment of Public Health, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
Sia-Seng TanDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
Yu-Cin FongDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
Yi-Ju ChenDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
Sheng-Hsuan WangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
Yun-Hsuan LiDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
Chun-Hong ChenNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan 350401, Taiwan.
Po-Lin ChenDepartment of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan 701401, Taiwan.
Guey-Chuen PerngInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
Jih-Jin TsaiTropical Medicine Center, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan.ORCID 0000-0003-2226-8916
National Cheng Kung University · TWNational Cheng Kung University Hospital · TWKaohsiung Medical University · TWNational Health Research Institutes · TW

Funding

Ministry of Health and Welfare, Taiwan MOHW109-TDU-B-212-114006 and MOHW110-TDU-B-212-124006Ministry of Science and Technology, Taiwan MOST 107-2314-B-006-063-MY3 and MOST 107-2321-B-006-002National Health Research Institute, Taiwan NHRI-110A1-MRCO-03212101
6 · The paper itself

Abstract

Hematopoietic stem and progenitor cells (HSPCs) mobilization is the movement of HSPCs from the bone marrow to the peripheral blood or tissue induced by stress. HSPC mobilization is a well-known response to protect the host during infection through urgent differentiation of HSPCs to immune cells. Dengue virus (DENV) infection is known to cause stress in infected humans and the mobilizing capacity of HSPCs during DENV infection in affected patients has not been fully investigated. Here, we investigated whether DENV infection can induce HSPC mobilization and if the mobilized HSPCs are permissive to DENV infection. White blood cells (WBCs) were collected from dengue patients (DENV+) and healthy donors and analyzed by flow cytometry and plaque assay. Elevated HSPCs levels were found in the WBCs of the DENV+ group when compared to the healthy group. Mobilization of HSPCs and homing markers (skin and gut) expression decreased as the patients proceeded from dengue without symptoms (DWoWS) to severe dengue (SD). Mobilizing HSPCs were not only permissive to DENV infection, but infectious DENV could be recovered after coculture. Our results highlight the need for further investigation into HSPC mobilization or alterations of hematopoiesis during viral infections such as DENV in order to develop appropriate countermeasures.

Indexed as

DengueHematopoietic Stem CellsBone MarrowBone Marrow CellsHematopoietic Stem Cell MobilizationHumansdenguedengue virusDENV infectionhematopoietic stem and progenitor cells (HSPCs)HSPCs mobilization

Identifiers

PMID36430807
PMCPMC9699116
OpenAlexW4309740535

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.