Evidence map›Paper›PMID 36430707›Full record

ArticleInternational journal of molecular sciences2022

Deglycosylation Increases the Aggregation and Angiogenic Properties of Mutant Tissue Inhibitor of Metalloproteinase 3 Protein: Implications for Sorsby Fundus Dystrophy.

Jian Hua Qi, Bela Anand-Apte

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. The TIMP protein family: diverse roles in pathophysiology.American journal of physiology. Cell physiology · 2024
    Review
  2. Review
  3. Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9.Matrix biology : journal of the International Society for Matrix Biology · 2023
    Article
  4. Short histological kaleidoscope - recent findings in histology. Part IV.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jian Hua QiDepartment of Ophthalmology, Cleveland Clinic Lerner College of Medicine, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Bela Anand-ApteDepartment of Ophthalmology, Cleveland Clinic Lerner College of Medicine, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.ORCID 0000-0002-4845-9094
Cleveland Clinic Lerner College of Medicine · US

Funding

RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI BELA ANAND-APTE · 2016 to 2026
$7.7M
Regulation of Choroidal Neovascularization in Sorsby's Fundus DystrophyR01EY027083 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI ANAND-APTE, BELA · 2017 to 2024
$4.0M
Role of Retinoic Acid in the Regulation of the Blood-Retinal Barrier.R01EY026181 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI ANAND-APTE, BELA · 2016 to 2020
$2.1M
Molecular insights into the pathogenesis of Sorsby Fundus DystrophyR21EY022768 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI QI, JIAN HUA · 2012 to 2013
$422k
NEI NIH HHS EY022768NEI NIH HHS EY026181NEI NIH HHS P30 EY025585NEI NIH HHS P30EY025585NEI NIH HHS R01 EY026181NEI NIH HHS R01 EY027083NEI NIH HHS R21 EY022768NIH HHS EY027083
6 · The paper itself

Abstract

Sorsby fundus dystrophy (SFD) is an autosomal dominant macular disorder caused by mutations in tissue Inhibitor of the metalloproteinase-3 (

Indexed as

Macular DegenerationTissue Inhibitor of Metalloproteinase-3Vascular Endothelial Growth Factor Receptor-2Endothelial CellsGlycosylationHumansMatrix MetalloproteinasesNeovascularization, PathologicProtein AggregatesVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsMatrix MetalloproteinasesProtein AggregatesTissue Inhibitor of Metalloproteinase-3Vascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth Factorsangiogenesisendothelial cellglycosylationmatrix metalloproteinasestissue inhibitor of matrix metalloproteinasevascular endothelial growth factor (VEGF)

Identifiers

PMID36430707
PMCPMC9696176
OpenAlexW4309281017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.