ReviewInternational journal of molecular sciences2022
Progesterone: The Key Factor of the Beginning of Life.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential.Frontiers in endocrinology · 2024Pooled it
- Effects of vaginal vs oral progesterone supplementation before embryo transfer on live birth rates and levels: a randomized trial.Reproduction & fertility · 2025Trial
- Effect of luteal-phase GnRH agonist on frozen-thawed embryo transfer during artificial cycles: a randomised clinical pilot study.Frontiers in endocrinology · 2023Trial
- Association between duration of progesterone supplementation and clinical outcomes in artificial frozen-thawed embryo transfer cycles.Frontiers in endocrinology · 2023Trial
- Assisted Reproductive Technologies (ART) and breast cancer risk: hormonal treatments under the spotlight.Breast cancer research and treatment · 2026Review
- Metroplasty before IVF in women with a T-shaped uterus: A clinical challenge.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Review
- Thermal-enhanced self-heating microneedle patch for sustained progesterone delivery and improved pregnancy maintenance.Materials today. Bio · 2026Article
- Immunometabolic-uterine-ovarian interactions and flushing therapy in dairy cows: a narrative review.Veterinary world · 2026Review
- A case report of acute hyperlipidemic pancreatitis after blastocyst transfer and literature review.Frontiers in medicine · 2026Article
- Integrated hormonal, metabolic, and epigenetic regulation of corpus luteum function: insights into steroidogenesis, angiogenesis, and regression.Frontiers in endocrinology · 2026Review
- Transcriptomic studies on the product stress response revealed that YCF1 is a beneficial factor for progesterone production inSynthetic and systems biotechnology · 2025Article
- Hormonal Crosstalk in Melasma: Unraveling the Dual Roles of Estrogen and Progesterone in Melanogenesis.International journal of molecular sciences · 2025Review
- Pregnancy and Dry Eye Syndrome: A Review for Clinical Practice.International journal of molecular sciences · 2025Review
- The Impact of Lifestyle on Reproductive Health: Microbial Complexity, Hormonal Dysfunction, and Pregnancy Outcomes.International journal of molecular sciences · 2025Review
- The Role of β-Core Fragment hCG in Embryo Implantation and Early Pregnancy.International journal of molecular sciences · 2025Article
- Article
- Gut Microbiome Dysbiosis and Its Impact on Reproductive Health: Mechanisms and Clinical Applications.Metabolites · 2025Review
- Encapsulation of progesterone in reishi mushroom composite for optimized hormone replacement and targeted anticancer therapy.RSC advances · 2025Article
- Preterm Birth in African American Women: A Multi-Omic Pilot Study in Early Pregnancy.Biological research for nursing · 2025Article
- Biological characteristics of spontaneous ovarian cancer inZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progesterone is the ovarian steroid produced by the granulosa cells of follicles after the LH peak at mid-cycle. Its role is to sustain embryo endometrial implantation and ongoing pregnancy. Other biological effects of progesterone may exert a protective function in supporting pregnancy up to birth. Luteal phase support (LPS) with progesterone is the standard of care for assisted reproductive technology. Progesterone vaginal administration is currently the most widely used treatment for LPS. Physicians and patients have been reluctant to change an administration route that has proven to be effective. However, some questions remain open, namely the need for LPS in fresh and frozen embryo transfer, the route of administration, the optimal duration of LPS, dosage, and the benefit of combination therapies. The aim of this review is to provide an overview of the uterine and extra-uterine effects of progesterone that may play a role in embryo implantation and pregnancy, and to discuss the advantages of the use of progesterone for LPS in the context of Good Medical Practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.