Evidence map›Paper›PMID 36430592›Full record

ArticleInternational journal of molecular sciences2022

Benzenesulfonamides Incorporating Hydantoin Moieties Effectively Inhibit Eukaryoticand Human Carbonic Anhydrases.

Morteza Abdoli, Viviana De Luca, Clemente Capasso, Claudiu T Supuran, Raivis Žalubovskis

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Investigation onPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Progress of Section "Biochemistry" in 2022.International journal of molecular sciences · 2023
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Morteza AbdoliInstitute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, P. Valdenaiela 3, LV-1048 Riga, Latvia.
Viviana De LucaDepartment of Biology, Agriculture and Food Sciences, Institute of Biosciences and Bioresources, Via Pietro Castellino 111, 80131 Napoli, Italy.
Clemente CapassoDepartment of Biology, Agriculture and Food Sciences, Institute of Biosciences and Bioresources, Via Pietro Castellino 111, 80131 Napoli, Italy.ORCID 0000-0003-3314-2411
Claudiu T SupuranNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.ORCID 0000-0003-4262-0323
Raivis ŽalubovskisInstitute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, P. Valdenaiela 3, LV-1048 Riga, Latvia.ORCID 0000-0002-9471-1342
Institute of Biosciences and Bioresources · ITRiga Technical University · LVUniversity of Florence · IT

Funding

EU European Regional Development Fund 1.1.1.2/VIAA/3/19/398
6 · The paper itself

Abstract

A series of novel 1-(4-benzenesulfonamide)-3-alkyl/benzyl-hydantoin derivatives were synthesized and evaluated for the inhibition of eukaryotic and human carbonic anhydrases (CAs, EC 4.2.1.1). The prepared compounds were screened for their hCA inhibitory activities against three cytosolic isoforms as well as two β-CAs from fungal pathogens. The best inhibition was observed against hCA II and VII as well as

Indexed as

Carbonic Anhydrase InhibitorsCarbonic AnhydrasesHydantoinsSulfonamidesBenzene DerivativesBenzenesulfonamidesEukaryotic CellsHumansStructure-Activity RelationshipBenzene DerivativesBenzenesulfonamidesCarbonic Anhydrase InhibitorsCarbonic AnhydrasesHydantoinsSulfonamidescarbonic anhydrase inhibitorshydantoinsulfonamides

Identifiers

PMID36430592
PMCPMC9696710
OpenAlexW4309309644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.