Evidence map›Paper›PMID 36430553›Full record

ArticleInternational journal of molecular sciences2022

Limitations of Tamoxifen Application for In Vivo Genome Editing Using Cre/ER

Leonid A Ilchuk, Nina I Stavskaya, Ekaterina A Varlamova, Alvina I Khamidullina, Victor V Tatarskiy, Vladislav A Mogila, Ksenia B Kolbutova, Sergey A Bogdan, Alexey M Sheremetov, Alexandr N Baulin and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Leonid A IlchukCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0002-0157-2102
Nina I StavskayaInstitute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, 119334 Moscow, Russia.
Ekaterina A VarlamovaCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0002-8451-1216
Alvina I KhamidullinaInstitute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, 119334 Moscow, Russia.
Victor V TatarskiyInstitute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, 119334 Moscow, Russia.ORCID 0000-0002-9080-5683
Vladislav A MogilaInstitute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, 119334 Moscow, Russia.
Ksenia B KolbutovaHead Center of Hygiene and Epidemiology of Federal Medical Biological Agency of Russia, 1st Pekhotniy Pereulok, 6, 123182 Moscow, Russia.
Sergey A BogdanHead Center of Hygiene and Epidemiology of Federal Medical Biological Agency of Russia, 1st Pekhotniy Pereulok, 6, 123182 Moscow, Russia.
Alexey M SheremetovHead Center of Hygiene and Epidemiology of Federal Medical Biological Agency of Russia, 1st Pekhotniy Pereulok, 6, 123182 Moscow, Russia.
Alexandr N BaulinHead Center of Hygiene and Epidemiology of Federal Medical Biological Agency of Russia, 1st Pekhotniy Pereulok, 6, 123182 Moscow, Russia.
Irina A FilatovaHead Center of Hygiene and Epidemiology of Federal Medical Biological Agency of Russia, 1st Pekhotniy Pereulok, 6, 123182 Moscow, Russia.
Yulia Yu SilaevaInstitute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, 119334 Moscow, Russia.
Maxim A FilatovCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Alexandra V BruterCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Institute of Gene Biology · RUFederal Medical-Biological Agency · RU

Funding

Russian Science Foundation 22-15-00227
6 · The paper itself

Abstract

Inducible Cre-dependent systems are frequently used to produce both conditional knockouts and transgenic mice with regulated expression of the gene of interest. Induction can be achieved by doxycycline-dependent transcription of the wild type gene or OH-tamoxifen-dependent nuclear translocation of the chimeric Cre/ER

Indexed as

DoxycyclineGene EditingTamoxifenAnimalsFemaleIntegrasesMiceMice, TransgenicCre recombinaseDoxycyclineIntegrasesTamoxifenconditional knockoutCre-ERT2Cre-LoxPcyclin-dependent kinases 8/19genetically engineered micegenome-edited micetamoxifen

Identifiers

PMID36430553
PMCPMC9694728
OpenAlexW4309312898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.