Evidence map›Paper›PMID 36430551›Full record

ReviewInternational journal of molecular sciences2022

Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions.

Elizaveta E Alemasova, Olga I Lavrik

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Elizaveta E AlemasovaInstitute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk 630090, Russia.ORCID 0000-0002-1537-5003
Olga I LavrikInstitute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk 630090, Russia.ORCID 0000-0001-5980-8889
Institute of Chemical Biology and Fundamental Medicine · RUNovosibirsk State University · RU

Funding

Russian Science Foundation 21-64-00017Russian Science Foundation 22-14-00112The Ministry of Higher Education and Science 121031300041-4
6 · The paper itself

Abstract

Biomolecular condensates are nonmembrane cellular compartments whose formation in many cases involves phase separation (PS). Despite much research interest in this mechanism of macromolecular self-organization, the concept of PS as applied to a live cell faces certain challenges. In this review, we discuss a basic model of PS and the role of site-specific interactions and percolation in cellular PS-related events. Using a multivalent poly(ADP-ribose) molecule as an example, which has high PS-driving potential due to its structural features, we consider how site-specific interactions and network formation are involved in the formation of phase-separated cellular condensates.

Indexed as

Poly Adenosine Diphosphate RiboseMacromolecular SubstancesMacromolecular SubstancesPoly Adenosine Diphosphate Ribosecondensateliquid–liquid phase separation (LLPS)PARPpoly(ADP-ribose) (PAR)

Identifiers

PMID36430551
PMCPMC9694962
OpenAlexW4309308804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.