Evidence map›Paper›PMID 36430532›Full record

ReviewInternational journal of molecular sciences2022

Impact of Reactive Species on Amino Acids-Biological Relevance in Proteins and Induced Pathologies.

Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Celia Andrés Juan, Francisco J Plou, Eduardo Pérez-Lebeña

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. The Oxidative Stress: Origin and Role in Aging and Diseases.Antioxidants (Basel, Switzerland) · 2026
    Review
  5. Article
  6. International journal of molecular sciences · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Metabolomic alterations in human brain microvascular endothelial cells induced by traumatic injury.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  13. Review
  14. Not So Bioorthogonal Chemistry.Journal of the American Chemical Society · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Posttranslational Modifications ofPharmacological reviews · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Celia María Curieses AndrésHospital Clínico Universitario of Valladolid, Avenida de Ramón y Cajal, 3, 47003 Valladolid, Spain.
José Manuel Pérez de la LastraInstitute of Natural Products and Agrobiology, CSIC-Spanish Research Council, Avda. Astrofísico Fco. Sánchez, 3, 38206 La Laguna, Spain.ORCID 0000-0003-4663-5565
Celia Andrés JuanCinquima Institute and Department of Organic Chemistry, Faculty of Sciences, Valladolid University, Paseo de Belén, 7, 47011 Valladolid, Spain.
Francisco J PlouInstitute of Catalysis and Petrochemistry, CSIC-Spanish Research Council, 28049 Madrid, Spain.ORCID 0000-0003-0831-893X
Eduardo Pérez-LebeñaSistemas de Biotecnología y Recursos Naturales, 47625 Valladolid, Spain.
Hospital Clínico Universitario de Valladolid · ESInstituto de Catálisis y Petroleoquímica · ESInstituto de Productos Naturales y Agrobiología · ESUniversidad de Valladolid · ES

Funding

Agencia Canaria de Investigación, Innovación y Sociedad de la Información ProID2020010134Cooperation Program INTERREG-MAC 2014-2020, with European Funds for Regional Devel-opment-FEDER APOGEOFundación CajaCanarias project 2019SP43
6 · The paper itself

Abstract

This review examines the impact of reactive species RS (of oxygen ROS, nitrogen RNS and halogens RHS) on various amino acids, analyzed from a reactive point of view of how during these reactions, the molecules are hydroxylated, nitrated, or halogenated such that they can lose their capacity to form part of the proteins or peptides, and can lose their function. The reactions of the RS with several amino acids are described, and an attempt was made to review and explain the chemical mechanisms of the formation of the hydroxylated, nitrated, and halogenated derivatives. One aim of this work is to provide a theoretical analysis of the amino acids and derivatives compounds in the possible positions. Tyrosine, methionine, cysteine, and tryptophan can react with the harmful peroxynitrite or

Indexed as

Amino AcidsCysteineMethionineProteinsTryptophanTyrosineAmino AcidsCysteineMethionineProteinsTryptophanTyrosineamino acidspathologiesproteinsreactive speciesreactive stressRHSRNSROS

Identifiers

PMID36430532
PMCPMC9692786
OpenAlexW4309210811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.