Evidence map›Paper›PMID 36430497›Full record

ArticleInternational journal of molecular sciences2022

Altered Cortical Palmitoylation Induces Widespread Molecular Disturbances in Parkinson's Disease.

Juan F Cervilla-Martínez, Juan J Rodríguez-Gotor, Krzysztof J Wypijewski, Ángela Fontán-Lozano, Tao Wang, Enrique Santamaría, William Fuller, Rebeca Mejías

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  8. Review
  9. Mechanisms and functions of protein S-acylation.Nature reviews. Molecular cell biology · 2024
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

Juan F Cervilla-MartínezDepartment of Physiology, School of Biology, University of Seville, Avenida de la Reina Mercedes, 6, 41012 Sevilla, Spain.
Juan J Rodríguez-GotorDepartment of Physiology, School of Biology, University of Seville, Avenida de la Reina Mercedes, 6, 41012 Sevilla, Spain.ORCID 0000-0002-3838-1115
Krzysztof J WypijewskiInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Ángela Fontán-LozanoDepartment of Physiology, School of Biology, University of Seville, Avenida de la Reina Mercedes, 6, 41012 Sevilla, Spain.ORCID 0000-0003-1646-0952
Tao WangMcKusick-Nathans Institute of Genetic Medicine and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Enrique SantamaríaClinical Neuroproteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), IDISNA, Irunlarrea Street, 3, 31008 Pamplona, Spain.ORCID 0000-0001-8046-8102
William FullerInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0002-5883-4433
Rebeca MejíasDepartment of Physiology, School of Biology, University of Seville, Avenida de la Reina Mercedes, 6, 41012 Sevilla, Spain.ORCID 0000-0003-1936-7219
Instituto de Biomedicina de Sevilla · ESInstituto de Neurociencias · ESJohns Hopkins University · USUniversidad de Sevilla · ESUniversidad Publica de Navarra · ESUniversity of Dundee · GBUniversity of Glasgow · GB

Funding

British Heart Foundation PG/19/5/34150National Institute of Health R21NS085358
6 · The paper itself

Abstract

The relationship between Parkinson's disease (PD), the second-most common neurodegenerative disease after Alzheimer's disease, and palmitoylation, a post-translational lipid modification, is not well understood. In this study, to better understand the role of protein palmitoylation in PD and the pathways altered in this disease, we analyzed the differential palmitoyl proteome (palmitome) in the cerebral cortex of PD patients compared to controls (

Indexed as

Neurodegenerative DiseasesParkinson DiseaseCerebral CortexHumansLipoylationMitochondriacerebral cortexinteractomepalmitoylationParkinson´s diseaseproteomics

Identifiers

PMID36430497
PMCPMC9696982
OpenAlexW4309008585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.