Evidence map›Paper›PMID 36430459›Full record

ArticleInternational journal of molecular sciences2022

Choline Improves Neonatal Hypoxia-Ischemia Induced Changes in Male but Not Female Rats.

Tayo Adeyemo, Ayodele Jaiyesimi, Jill G Bumgardner, Charity Lohr, Aditi Banerjee, Mary C McKenna, Jaylyn Waddell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tayo AdeyemoDepartment of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.
Ayodele JaiyesimiDepartment of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.
Jill G BumgardnerDepartment of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.
Charity LohrDepartment of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.ORCID 0000-0001-8226-7419
Aditi BanerjeeDepartment of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.
Mary C McKennaDepartment of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.ORCID 0000-0002-5236-3853
Jaylyn WaddellDepartment of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore St., Baltimore, MD 21201, USA.
University of Maryland, Baltimore · US

Funding

Project IV- Cerebellar Function After Hypoxia-Ischemia and Precipitating InflammationP01HD085928 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI BEARER, CYNTHIA FRANCES, MCCARTHY, MARGARET M. · 2016 to 2020
$6.3M
NICHD NIH HHS P01 HD085928NIH HHS P01HD085928NIH HHS R03HD085928
6 · The paper itself

Abstract

Choline is an essential nutrient with many roles in brain development and function. Supplementation of choline in early development can have long-lasting benefits. Our experiments aimed to determine the efficacy of choline supplementation in a postnatal day (PND) 10 rat model of neonatal hypoxia ischemia (HI) at term using both male and female rat pups. Choline (100 mg/kg) or saline administration was initiated the day after birth and given daily for 10 or 14 consecutive days. We determined choline's effects on neurite outgrowth of sex-specific cultured cerebellar granule cells after HI with and without choline. The magnitude of tissue loss in the cerebrum was determined at 72 h after HI and in adult rats. The efficacy of choline supplementation in improving motor ability and learning, tested using eyeblink conditioning, were assessed in young adult male and female rats. Overall, we find that choline improves neurite outgrowth, short-term histological measures and learning ability in males. Surprisingly, choline did not benefit females, and appears to exacerbate HI-induced changes.

Indexed as

CholineHypoxia-Ischemia, BrainAnimalsAnimals, NewbornFemaleIschemiaMaleRatsCholinecholineeyeblink conditioninghypoxia ischemianeonateneurite outgrowthsex differences

Identifiers

PMID36430459
PMCPMC9694200
OpenAlexW4309008718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.