Evidence map›Paper›PMID 36430407›Full record

ArticleInternational journal of molecular sciences2022

Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation.

Hadrián Álvarez-Fernández, Patricia Mingo-Casas, Ana-Belén Blázquez, Flavia Caridi, Juan Carlos Saiz, María-Jesús Pérez-Pérez, Miguel A Martín-Acebes, Eva-María Priego

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Neutral sphingomyelinase 2: A promising drug target for CNS disease.Advances in pharmacology (San Diego, Calif.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hadrián Álvarez-FernándezInstituto de Química Médica (IQM), CSIC, 28006 Madrid, Spain.
Patricia Mingo-CasasDepartment of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), CSIC, 28040 Madrid, Spain.ORCID 0000-0003-1207-240X
Ana-Belén BlázquezDepartment of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), CSIC, 28040 Madrid, Spain.ORCID 0000-0002-0847-0977
Flavia CaridiDepartment of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), CSIC, 28040 Madrid, Spain.
Juan Carlos SaizDepartment of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), CSIC, 28040 Madrid, Spain.ORCID 0000-0001-8269-5544
María-Jesús Pérez-PérezInstituto de Química Médica (IQM), CSIC, 28006 Madrid, Spain.ORCID 0000-0003-1336-7760
Miguel A Martín-AcebesDepartment of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), CSIC, 28040 Madrid, Spain.ORCID 0000-0001-6015-3613
Eva-María PriegoInstituto de Química Médica (IQM), CSIC, 28006 Madrid, Spain.ORCID 0000-0001-9470-4508
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria · ESInstituto de Química Médica · ES

Funding

European Commission - NextGenerationEU-CSIC's Global Health Platform SGL2103051European Commission - NextGenerationEU-CSIC's Global Health Platform SGL2103053Spanish Ministry of Science and Innovation PID2019-105117RR-C21Spanish Ministry of Science and Innovation PID2019-105117RR-C22Spanish National Research Council PIE-201980E100
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

West Nile virusZika VirusZika Virus InfectionAllosteric SiteAntiviral AgentsHumansSphingomyelin PhosphodiesteraseAntiviral AgentsSphingomyelin Phosphodiesteraseallosteric inhibitionflavivirushost-targeted antiviralsnSMase2

Identifiers

PMID36430407
PMCPMC9697135
OpenAlexW4309009370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.