Evidence map›Paper›PMID 36430384›Full record

ArticleInternational journal of molecular sciences2022

Conservation of Importin α Function in Apicomplexans: Ivermectin and GW5074 Target

Sujata B Walunj, Chunxiao Wang, Kylie M Wagstaff, Swati Patankar, David A Jans

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sujata B WalunjMolecular Parasitology Lab., Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Chunxiao WangNuclear Signalling Lab., Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Monash, VIC 3800, Australia.
Kylie M WagstaffNuclear Signalling Lab., Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Monash, VIC 3800, Australia.
Swati PatankarMolecular Parasitology Lab., Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
David A JansNuclear Signalling Lab., Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Monash, VIC 3800, Australia.ORCID 0000-0001-5115-4745
Monash University · AUIndian Institute of Technology Bombay · IN

Funding

Department of Science and Technology (DST), Science and Engineering Research Board CRG/2018/000129IITB/Monash University IMURA 0716National Health and Medical Research Council of Australia APP1002486National Health and Medical Research Council of Australia APP1103050
6 · The paper itself

Abstract

Signal-dependent transport into and out of the nucleus mediated by members of the importin (IMP) superfamily of nuclear transporters is critical to the eukaryotic function and a point of therapeutic intervention with the potential to limit disease progression and pathogenic outcomes. Although the apicomplexan parasites

Indexed as

alpha KaryopherinsParasitesAnimalsIndolesIvermectinMammalsMiceNuclear Localization SignalsPhenolsPlasmodium falciparumProtein Binding5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinonealpha KaryopherinsIndolesIvermectinNuclear Localization SignalsPhenolsimportinsmalarianuclear importnuclear import inhibitorstoxoplasmosis

Identifiers

PMID36430384
PMCPMC9695642
OpenAlexW4309009388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.