Evidence map›Paper›PMID 36430330›Full record

ReviewInternational journal of molecular sciences2022

The Role of Copper Homeostasis in Brain Disease.

Yumei An, Sunao Li, Xinqi Huang, Xueshi Chen, Haiyan Shan, Mingyang Zhang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 1 synthesis or guideline pooled it, 174 citations in OpenAlex.

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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yumei AnInstitute of Forensic Sciences, Suzhou Medical College, Soochow University, Suzhou 215000, China.
Sunao LiInstitute of Forensic Sciences, Suzhou Medical College, Soochow University, Suzhou 215000, China.
Xinqi HuangInstitute of Forensic Sciences, Suzhou Medical College, Soochow University, Suzhou 215000, China.
Xueshi ChenInstitute of Forensic Sciences, Suzhou Medical College, Soochow University, Suzhou 215000, China.
Haiyan ShanDepartment of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215000, China.
Mingyang ZhangInstitute of Forensic Sciences, Suzhou Medical College, Soochow University, Suzhou 215000, China.ORCID 0000-0001-7084-6237
Soochow University · CNNanjing Medical University · CN

Funding

Jiangsu 333 High Level Talent Training Project 2022Jiangsu Talent Youth Medical Program QNRC2016245National Natural Science Foundation of China No. 82071382, No. 81601306Shanghai Key Lab of Forensic Medicine KF2102Suzhou Science and Technology Development Project SYS2020089The Fifth Batch of Gusu District Health Talent Training Project GSWS2019060The Jiangsu Maternal and Child Health Research Key Project F202013The Priority Academic Program Development of Jiangsu Higher Education Institutions PAPD
6 · The paper itself

Abstract

In the human body, copper is an important trace element and is a cofactor for several important enzymes involved in energy production, iron metabolism, neuropeptide activation, connective tissue synthesis, and neurotransmitter synthesis. Copper is also necessary for cellular processes, such as the regulation of intracellular signal transduction, catecholamine balance, myelination of neurons, and efficient synaptic transmission in the central nervous system. Copper is naturally present in some foods and is available as a dietary supplement. Only small amounts of copper are typically stored in the body and a large amount of copper is excreted through bile and urine. Given the critical role of copper in a breadth of cellular processes, local concentrations of copper and the cellular distribution of copper transporter proteins in the brain are important to maintain the steady state of the internal environment. The dysfunction of copper metabolism or regulatory pathways results in an imbalance in copper homeostasis in the brain, which can lead to a myriad of acute and chronic pathological effects on neurological function. It suggests a unique mechanism linking copper homeostasis and neuronal activation within the central nervous system. This article explores the relationship between impaired copper homeostasis and neuropathophysiological progress in brain diseases.

Indexed as

Brain DiseasesCopperBrainCentral Nervous SystemHomeostasisHumansCopperbrain injurycognitioncoppercuproptosisneurodegeneration

Identifiers

PMID36430330
PMCPMC9698384
OpenAlexW4308876866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.