Evidence map›Paper›PMID 36430266›Full record

ArticleInternational journal of molecular sciences2022

Microbiota-Derived Extracellular Vesicles Detected in Human Blood from Healthy Donors.

Béatrice Schaack, Thomas Hindré, Nyamekye Quansah, Dalil Hannani, Corinne Mercier, David Laurin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 42 citations in OpenAlex.

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  13. Human gut commensalGut microbes · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Béatrice SchaackCNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Université Grenoble Alpes, 38000 Grenoble, France.ORCID 0000-0002-3008-7309
Thomas HindréCNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Université Grenoble Alpes, 38000 Grenoble, France.
Nyamekye QuansahCNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Université Grenoble Alpes, 38000 Grenoble, France.
Dalil HannaniCNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Université Grenoble Alpes, 38000 Grenoble, France.ORCID 0000-0001-5097-1401
Corinne MercierCNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Université Grenoble Alpes, 38000 Grenoble, France.ORCID 0000-0003-4118-1904
David LaurinEtablissement Français du Sang, Département Scientifique Auvergne Rhône-Alpes,38000 Grenoble, France.ORCID 0000-0001-9339-8369
Institut polytechnique de Grenoble · FRCentre National de la Recherche Scientifique · FR

Funding

Agence Nationale de la Recherche ANR-15-IDEX-02Établissement Français du Sang 2020-2021Grenoble Alpes University TIMC Emergence program "LTEE-vesi"
6 · The paper itself

Abstract

The microbiota constitutes an important part of the holobiont in which extracellular vesicles (EVs) are key players in health, especially regarding inter- and intra-kingdom communications. Analysis of EVs from the red blood cell concentrates of healthy donors revealed variable amounts of OmpA and LPS in 12 of the 14 analyzed samples, providing indirect experimental evidence of the presence of microbiota EVs in human circulating blood in the absence of barrier disruption. To investigate the role of these microbiota EVs, we tracked the fusion of fluorescent

Indexed as

Extracellular VesiclesMicrobiotaErythrocytesEscherichia coliHealth StatusHumansMonocytesextracellular vesicles (EVs)gut microbiotalipopolysaccharide (LPS)membrane fusionOmpAouter membrane vesicles (OMVs)red blood cell concentrates

Identifiers

PMID36430266
PMCPMC9696020
OpenAlexW4308869985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.