Evidence map›Paper›PMID 36430229›Full record

ReviewInternational journal of molecular sciences2022

Influence of the Microbiome Metagenomics and Epigenomics on Gastric Cancer.

Precious Mathebela, Botle Precious Damane, Thanyani Victor Mulaudzi, Zilungile Lynette Mkhize-Khwitshana, Guy Roger Gaudji, Zodwa Dlamini

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Precious MathebelaDepartment of Surgery, Steve Biko Academic Hospital, University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0003-2794-0222
Botle Precious DamaneDepartment of Surgery, Steve Biko Academic Hospital, University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0003-3060-5572
Thanyani Victor MulaudziDepartment of Surgery, Steve Biko Academic Hospital, University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0003-4071-3905
Zilungile Lynette Mkhize-KhwitshanaSchool of Medicine, University of Kwa-Zulu Natal, Durban, KwaZulu-Natal 4013, South Africa.ORCID 0000-0002-0373-9973
Guy Roger GaudjiDepartment of Urology, Level 7, Bridge C, Steve Biko Academic Hospital, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Arcadia 0007, South Africa.
Zodwa DlaminiSAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0002-8012-3646
Steve Biko Hospital · ZASouth African Medical Research Council · ZA

Funding

Department of Surgery, University of Pretoria, the South African Medical Research Council (SAMRC) 23108the National Research Foundation (NRF) 138139
6 · The paper itself

Abstract

Gastric cancer (GC) is one of the major causes of cancer deaths worldwide. The disease is seldomly detected early and this limits treatment options. Because of its heterogeneous and complex nature, the disease remains poorly understood. The literature supports the contribution of the gut microbiome in the carcinogenesis and chemoresistance of GC. Drug resistance is the major challenge in GC therapy, occurring as a result of rewired metabolism. Metabolic rewiring stems from recurring genetic and epigenetic factors affecting cell development. The gut microbiome consists of pathogens such as

Indexed as

Helicobacter pyloriMicrobiotaStomach NeoplasmsCarcinogenesisDysbiosisEpigenomicsHumansMetagenomicsNeoplasm Recurrence, Localasbestos-induced GCdysbiosisepigenomicsgastric cancer (GC)H. pyloriinflammasomemetabolitesmicrobiomeobesitypersonalized therapy

Identifiers

PMID36430229
PMCPMC9693604
OpenAlexW4308718868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.