Evidence map›Paper›PMID 36430148›Full record

ReviewInternational journal of molecular sciences2022

The Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer.

Ieva Vaicekauskaitė, Rasa Sabaliauskaitė, Juozas Rimantas Lazutka, Sonata Jarmalaitė

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Overexpression of cat eye syndrome chromosome region, candidate 2 in esophageal squamous carcinoma cell promotes tumor aggressiveness by facilitating NF-κB signaling and inhibition of p53-associated apoptosis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Genetic and Epigenetic Interactions Involved in Senescence of Stem Cells.International journal of molecular sciences · 2024
    Review
  10. Review
  11. The role of SWI/SNF complexes in digestive system neoplasms.Medical oncology (Northwood, London, England) · 2024
    Review
  12. A Novel DNA Variant inInternational journal of molecular sciences · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ieva VaicekauskaitėLaboratory of Genetic Diagnostic, National Cancer Institute, Santariškių 1, LT-08406 Vilnius, Lithuania.ORCID 0000-0003-3536-4384
Rasa SabaliauskaitėLaboratory of Genetic Diagnostic, National Cancer Institute, Santariškių 1, LT-08406 Vilnius, Lithuania.ORCID 0000-0002-3465-3558
Juozas Rimantas LazutkaInstitute of Biosciences, Vilnius University, Sauletekio Avenue 7, LT-10222 Vilnius, Lithuania.ORCID 0000-0002-1338-9575
Sonata JarmalaitėInstitute of Biosciences, Vilnius University, Sauletekio Avenue 7, LT-10222 Vilnius, Lithuania.ORCID 0000-0003-3719-0891
Vilnius University · LTNational Cancer Institute · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer (OC) is the fifth leading cause of women's death from cancers. The high mortality rate is attributed to the late presence of the disease and the lack of modern diagnostic tools, including molecular biomarkers. Moreover, OC is a highly heterogeneous disease, which contributes to early treatment failure. Thus, exploring OC molecular mechanisms could significantly enhance our understanding of the disease and provide new treatment options. Chromatin remodeling complexes (CRCs) are ATP-dependent molecular machines responsible for chromatin reorganization and involved in many DNA-related processes, including transcriptional regulation, replication, and reparation. Dysregulation of chromatin remodeling machinery may be related to cancer development and chemoresistance in OC. Some forms of OC and other gynecologic diseases have been associated with mutations in specific CRC genes. Most notably,

Indexed as

Chromatin Assembly and DisassemblyOvarian NeoplasmsActinsCarcinoma, Ovarian EpithelialChromosomal Proteins, Non-HistoneDNA-Binding ProteinsDNA HelicasesFemaleHumansMutationNuclear ProteinsNucleoproteinsTrans-ActivatorsTranscription FactorsActinsACTL6A protein, humanCHRAC1 protein, humanChromosomal Proteins, Non-HistoneDNA-Binding ProteinsDNA HelicasesNuclear ProteinsNucleoproteinsRSF1 protein, humanSMARCA4 protein, humanTrans-ActivatorsTranscription FactorsARID1ACHDchromatin remodeling complexesINO80ISWIovarian cancerSWI/SNF

Identifiers

PMID36430148
PMCPMC9697406
OpenAlexW4308512099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.