Evidence map›Paper›PMID 36429250›Full record

ArticleFoods (Basel, Switzerland)2022

Industrial Hemp (

Mattia Spano, Giacomo Di Matteo, Cinzia Ingallina, Anatoly Petrovich Sobolev, Anna Maria Giusti, Giuliana Vinci, Silvia Cammarone, Carola Tortora, Lara Lamelza, Sabrina Antonia Prencipe and 5 more

Open access · goldAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Research Progress on Flowering Period of Hemp.Plants (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Article
  4. The protective effect ofFrontiers in nutrition · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Mattia SpanoDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-5035-0971
Giacomo Di MatteoDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-0110-5010
Cinzia IngallinaDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0003-4817-7318
Anatoly Petrovich SobolevMagnetic Resonance Laboratory "Segre-Capitani", Institute for Biological Systems, CNR, Via Salaria Km 29.300, 00015 Monterotondo, Italy.ORCID 0000-0001-8709-7666
Anna Maria GiustiDepartment of Experimental Medicine, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-5694-3732
Giuliana VinciDepartment of Management, Sapienza University of Rome, Via del Castro Laurenziano 9, 00161 Rome, Italy.ORCID 0000-0003-3025-1831
Silvia CammaroneDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-3362-6363
Carola TortoraDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Lara LamelzaDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-8100-5943
Sabrina Antonia PrencipeDepartment of Management, Sapienza University of Rome, Via del Castro Laurenziano 9, 00161 Rome, Italy.ORCID 0000-0003-4766-1001
Laura GobbiDepartment of Management, Sapienza University of Rome, Via del Castro Laurenziano 9, 00161 Rome, Italy.
Bruno BottaDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-8707-4333
Federico MariniDepartment of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-8266-1117
Enio CampigliaDepartment of Agricultural and Forest Sciences, University of Tuscia, Via San Camillo de Lellis Snc, 01100 Viterbo, Italy.
Luisa ManninaDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-8659-5890
Sapienza University of Rome · ITInstitute for Technologies Applied to Cultural Heritage · ITUniversità degli Studi della Tuscia · IT

Funding

Ministry of Education, Universities and Research Dipartimenti di Eccellenza-L. 232/2016Regione Lazio LACanapa" Project (Progetto di Ricerca, finanziato ai sensi della L.R. 13/08 -Protocol 85-2017-15069 CUP: B86C18000730002
6 · The paper itself

Abstract

In this study, the effect of several agronomical practices on the chemical composition of hemp inflorescences, a potential novel food that needs to be further studied, was observed. Here, the case study of inflorescences from Ferimon cultivars is discussed and submitted to different agronomical practices (irrigation and fertilizers) in different years, and the inflorescences harvested in different periods were analyzed by a multimethodological approach. Targeted and untargeted methodologies allowed cannabinoids, total phenolic content, metabolite profile and antioxidant activity to be determined. The biomass and inflorescence yields were also reported. The whole data set was submitted to ANOVA-simultaneous component analysis. The statistic results allowed us to observe that irrigation was responsible for the (-)-Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) increment. THC, cannabichromene (CBC), cannabigerol (CBG), succinate, and fructose resulted as higher in full female flowering than in the period of seed maturity. On the other hand, nitrogen supplementation led to an increase of iso-leucine, valine, and threonine. The obtained results underlined both the potential food application of hemp inflorescences, due to the rich chemical profile, and the strong effect of agronomical practices, mainly irrigation and harvesting, on the qualitative and quantitative characteristics of its metabolite profile.

Indexed as

agronomical practiceschemical profilefertilizationharvestingindustrial hemp

Identifiers

PMID36429250
PMCPMC9689267
OpenAlexW4309613950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.