Evidence map›Paper›PMID 36429099›Full record

ArticleCells2022

Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation.

Louise Berkhoudt Lassen, Maj Schneider Thomsen, Elisa Basso, Ernst-Martin Füchtbauer, Annette Füchtbauer, Tiago Fleming Outeiro, Poul Henning Jensen, Torben Moos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Louise Berkhoudt LassenDANDRITE, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Maj Schneider ThomsenNeurobiology Research and Drug Delivery, Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.
Elisa BassoCenter for Biostructural Imaging of Neurodegeneration, Department of Experimental Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany.
Ernst-Martin FüchtbauerDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Annette FüchtbauerDepartment of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Tiago Fleming OuteiroCenter for Biostructural Imaging of Neurodegeneration, Department of Experimental Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany.
Poul Henning JensenDANDRITE, Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0002-4439-9020
Torben MoosNeurobiology Research and Drug Delivery, Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0001-9989-0207
Aarhus University · DKAalborg University · DKUniversitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overexpression of α-synuclein with tyrosine mutated to phenylalanine at position 125 leads to a severe phenotype with motor impairment and neuropathology in

Indexed as

alpha-SynucleinNeurotoxicity SyndromesAnimalsHumansMiceMice, TransgenicMutationPhenylalanineSerineTyrosinealpha-SynucleinPhenylalanineSerineTyrosineaggregatesalpha-synucleinbehaviorcortico-spinal tractneurodegenerationoligodendrocyteParkinson’s diseaseserinetransgenetyrosine

Identifiers

PMID36429099
PMCPMC9688722
OpenAlexW4309787448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.