Evidence map›Paper›PMID 36429092›Full record

ReviewCells2022

Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential.

Farheen Badrealam Khan, Shahab Uddin, Abozer Y Elderdery, Khang Wen Goh, Long Chiau Ming, Chrismawan Ardianto, Abdul Rasheed Palakot, Irfa Anwar, Mohsina Khan, Mohammad Owais and 10 more

Abstract readReview
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Farheen Badrealam KhanDepartment of Biology, College of Science, The United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Shahab UddinTranslational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar.ORCID 0000-0003-1886-6710
Abozer Y ElderderyDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia.ORCID 0000-0002-6219-5312
Khang Wen GohFaculty of Data Sciences and Information Technology, INTI International University, Nilai 78100, Malaysia.ORCID 0000-0001-6686-7019
Long Chiau MingPAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Gadong BE1410, Brunei.ORCID 0000-0002-6971-1383
Chrismawan ArdiantoDepartment of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.ORCID 0000-0003-3713-7900
Abdul Rasheed PalakotDepartment of Biology, College of Science, The United Arab Emirates University, Al Ain 15551, United Arab Emirates.ORCID 0000-0002-5958-718X
Irfa AnwarDepartment of Biology, College of Science, The United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Mohsina KhanDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Mohammad OwaisInterdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, UP, India.
Chih-Yang HuangDepartment of Biotechnology, Asia University, Taichung 404, Taiwan.ORCID 0000-0003-2347-0411
Jayasimha Rayalu DaddamDepartment of Ruminant Science, Institute of Animal Sciences, Agriculture Research Organization, Volcani Center, Rishon Lezion 7505101, Israel.ORCID 0000-0002-0666-8517
Meraj Alam KhanProgram in Translational Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children & DigiBiomics Inc, Toronto, ON M51X8, Canada.
Shoaib ShoaibDepartment Biochemistry, Jawaharlal Nehru Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh 202002, UP, India.
Md KhursheedCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai 505055, United Arab Emirates.
Sara ReshadatDepartment of Internal Medicine, Semnan University of Medical Sciences, Semnan 3513119111, Iran.
Hamid Reza Khayat KashaniImam Hossein Hospital, Madani Street, Tehran 1617763141, Iran.ORCID 0000-0003-3711-6763
Sameer MirzaDepartment of Chemistry, United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Abbas A KhaleelDepartment of Chemistry, United Arab Emirates University, Al Ain 15551, United Arab Emirates.ORCID 0000-0002-0346-384X
Mohammed Akli AyoubDepartment of Biology, College of Science, The United Arab Emirates University, Al Ain 15551, United Arab Emirates.ORCID 0000-0003-0022-578X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.

Indexed as

Cardiovascular DiseasesCardiovascular SystemExosomesBiomarkersHumansRNA, UntranslatedBiomarkersRNA, Untranslatedcardiovascular diseasecircRNAexosomeslncRNAmiRNAncRNA

Identifiers

PMID36429092
PMCPMC9688392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.