Evidence map›Paper›PMID 36429089›Full record

ArticleCells2022

Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary

Carsten Schwan, Alexander E Lang, Andreas Schlosser, Setsuko Fujita-Becker, Abdulatif AlHaj, Rasmus R Schröder, Jan Faix, Klaus Aktories, Hans Georg Mannherz

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. The Rho GTPase signaling pathway modulatesFrontiers in immunology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Carsten SchwanInstitute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwig-University, 79104 Freiburg, Germany.
Alexander E LangInstitute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwig-University, 79104 Freiburg, Germany.
Andreas SchlosserRudolf Virchow Center of Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
Setsuko Fujita-BeckerCryo-Electron Microscopy, BioQuant, University Hospital, 69120 Heidelberg, Germany.
Abdulatif AlHajDepartment of Anatomy and Molecular Embryology, Ruhr-University, 44780 Bochum, Germany.ORCID 0000-0002-0768-114X
Rasmus R SchröderCryo-Electron Microscopy, BioQuant, University Hospital, 69120 Heidelberg, Germany.
Jan FaixInstitute of Biophysical Chemistry, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0003-1803-9192
Klaus AktoriesInstitute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwig-University, 79104 Freiburg, Germany.ORCID 0000-0002-5397-0436
Hans Georg MannherzDepartment of Anatomy and Molecular Embryology, Ruhr-University, 44780 Bochum, Germany.ORCID 0000-0001-8158-5722
University of Freiburg · DEHeidelberg University · DERuhr University Bochum · DEMedizinische Hochschule Hannover · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clostridioides bacteria are responsible for life threatening infections. Here, we show that in addition to actin, the binary toxins CDT, C2I, and Iota from

Indexed as

Actin-Related Protein 2-3 ComplexBacterial ToxinsActinsAdenosine DiphosphateADP Ribose TransferasesADP-RibosylationAnimalsCaco-2 CellsClostridioidesHumansMiceActin-Related Protein 2-3 ComplexActinsAdenosine DiphosphateADP Ribose TransferasesARPC2 protein, humanBacterial ToxinsactinADP-ribosyltransferasesArp2/3 complexClostridioides binary toxins

Identifiers

PMID36429089
PMCPMC9688287
OpenAlexW4309461070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.