Evidence map›Paper›PMID 36429057›Full record

ArticleCells2022

Intracellular Injection of Brain Extracts from Alzheimer's Disease Patients Triggers Unregulated Ca

Anna Pensalfini, Abdul Rahim Umar, Charles Glabe, Ian Parker, Ghanim Ullah, Angelo Demuro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. In Vitro Models of Amyotrophic Lateral Sclerosis.Cellular and molecular neurobiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anna PensalfiniDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Abdul Rahim UmarDepartment of Physics, University of South Florida, Tampa, FL 33620, USA.
Charles GlabeDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Ian ParkerDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.ORCID 0000-0001-8734-4081
Ghanim UllahDepartment of Physics, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0002-3716-8742
Angelo DemuroDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
University of California, Irvine · USUniversity of South Florida · US

Funding

Multi-scale observation and modeling of IP3/Ca signalingR01GM065830 · NIGMS · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI MAK, DON-ON DANIEL, PARKER, IAN · 2002 to 2017
$10.7M
National Institute of Health R01AG053988NIH HHS R01GM065830NIH HHS RF1AG056507-01
6 · The paper itself

Abstract

Strong evidence indicates that amyloid beta (Aβ) inflicts its toxicity in Alzheimer's disease (AD) by promoting uncontrolled elevation of cytosolic Ca

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBrainCalciumEnergy MetabolismHumansAmyloid beta-PeptidesCalciumAlzheimer’samyloid beta (Aβ)cellular bioenergeticsendoplasmic reticuluminositol 1,4,5-trisphospahte receptorsupregulated calcium signaling

Identifiers

PMID36429057
PMCPMC9688564
OpenAlexW4309609232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.