Evidence map›Paper›PMID 36429023›Full record

ArticleCells2022

Survival Pathways of HIF-Deficient Tumour Cells: TCA Inhibition, Peroxisomal Fatty Acid Oxidation Activation and an AMPK-PGC-1α Hypoxia Sensor.

Monika A Golinska, Marion Stubbs, Adrian L Harris, Laszlo G Boros, Madhu Basetti, Dominick J O McIntyre, John R Griffiths

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Monika A GolinskaCancer Research UK Cambridge Institute, Cambridge University, Li Ka Shing Centre, Cambridge CB2 0RE, UK.ORCID 0000-0003-3679-8782
Marion StubbsCancer Research UK Cambridge Institute, Cambridge University, Li Ka Shing Centre, Cambridge CB2 0RE, UK.
Adrian L HarrisHypoxia and Angiogenesis Group, Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford OX3 9DS, UK.ORCID 0000-0003-1376-8409
Laszlo G BorosDepartment of Pediatrics, Harbor-UCLA Medical Center, University of California Los Angeles School of Medicine, Los Angeles, CA 90502, USA.
Madhu BasettiCancer Research UK Cambridge Institute, Cambridge University, Li Ka Shing Centre, Cambridge CB2 0RE, UK.ORCID 0000-0001-5844-856X
Dominick J O McIntyreCancer Research UK Cambridge Institute, Cambridge University, Li Ka Shing Centre, Cambridge CB2 0RE, UK.
John R GriffithsCancer Research UK Cambridge Institute, Cambridge University, Li Ka Shing Centre, Cambridge CB2 0RE, UK.ORCID 0000-0001-7369-6836
University of Cambridge · GBUniversity of California, Los Angeles · USUniversity of Oxford · GB

Funding

Cancer Research UK 11359Cancer Research UK 18974Cancer Research UK C14303/A17197Cancer Research UK C9545/A17197Cancer Research UK C9545/A29580
6 · The paper itself

Abstract

The HIF-1 and HIF-2 (HIF1/2) hypoxia responses are frequently upregulated in cancers, and HIF1/2 inhibitors are being developed as anticancer drugs. How could cancers resist anti-HIF1/2 therapy? We studied metabolic and molecular adaptations of HIF-1β-deficient Hepa-1c4, a hepatoma model lacking HIF1/2 signalling, which mimics a cancer treated by a totally effective anti-HIF1/2 agent. [1,2-

Indexed as

AMP-Activated Protein KinasesHydrogen PeroxideAdenosine TriphosphateCell HypoxiaFatty AcidsHumansHypoxiaHypoxia-Inducible Factor 1Adenosine TriphosphateAMP-Activated Protein KinasesFatty AcidsHydrogen PeroxideHypoxia-Inducible Factor 11,2-13C2-labelled glucoseAMP-activated kinasefatty acid oxidationHepa-1 c4 cellsHIF-1β deficiencyhypoxia responsePGC-1αphospho-p38 MAPKPPARαTCA

Identifiers

PMID36429023
PMCPMC9688062
OpenAlexW4309214386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.