Evidence map›Paper›PMID 36428974›Full record

ArticleCells2022

CircANKRD12 Is Induced in Endothelial Cell Response to Oxidative Stress.

Christine Voellenkle, Paola Fuschi, Martina Mutoli, Matteo Carrara, Paolo Righini, Giovanni Nano, Carlo Gaetano, Fabio Martelli

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. The Landscape of Circular RNAs in Cardiovascular Diseases.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Christine VoellenkleMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.ORCID 0000-0003-0824-060X
Paola FuschiMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.
Martina MutoliMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.ORCID 0000-0002-9751-2242
Matteo CarraraMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.
Paolo RighiniOperative Unit of Vascular & Endovascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.ORCID 0000-0002-4038-5406
Giovanni NanoOperative Unit of Vascular & Endovascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.
Carlo GaetanoLaboratorio di Epigenetica, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Fabio MartelliMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.ORCID 0000-0002-8624-7738
IRCCS Policlinico San Donato · ITIstituti Clinici Scientifici Maugeri · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Redox imbalance of the endothelial cells (ECs) plays a causative role in a variety of cardiovascular diseases. In order to better understand the molecular mechanisms of the endothelial response to oxidative stress, the involvement of circular RNAs (circRNAs) was investigated. CircRNAs are RNA species generated by a "back-splicing" event, which is the covalent linking of the 3'- and 5'-ends of exons. Bioinformatics analysis of the transcriptomic landscape of human ECs exposed to H

Indexed as

MicroRNAsRNA, CircularHumansHuman Umbilical Vein Endothelial CellsHydrogen PeroxideNuclear ProteinsOxidative StressTumor Suppressor Protein p53ANKRD12 protein, humanHydrogen PeroxideMicroRNAsNuclear ProteinsRNA, CircularTumor Suppressor Protein p53circRNA–miRNA–mRNA regulatory networkcircular RNAsendotheliumFoxo signaling pathwayoxidative stressp53 signaling pathway

Identifiers

PMID36428974
PMCPMC9688326
OpenAlexW4308711950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.