Evidence map›Paper›PMID 36428884›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Analysis of Gene Single Nucleotide Polymorphisms in COVID-19 Disease Highlighting the Susceptibility and the Severity towards the Infection.

Mario Giosuè Balzanelli, Pietro Distratis, Rita Lazzaro, Van Hung Pham, Toai Cong Tran, Gianna Dipalma, Angelica Bianco, Emilio Maria Serlenga, Sergey Khachatur Aityan, Valentina Pierangeli and 4 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. Article
  8. Association Between Genetic Variants inDiagnostics (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Genetic variants inFrontiers in genetics · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Mario Giosuè BalzanelliSET-118, Department of Pre-Hospital and Emergency-San Giuseppe Moscati Hospital, 74100 Taranto, Italy.
Pietro DistratisSET-118, Department of Pre-Hospital and Emergency-San Giuseppe Moscati Hospital, 74100 Taranto, Italy.
Rita LazzaroSET-118, Department of Pre-Hospital and Emergency-San Giuseppe Moscati Hospital, 74100 Taranto, Italy.
Van Hung PhamDepartment of Microbiology and Virology, Phan Chau Trinh University of Medicine, Danang City 50000, Vietnam.
Toai Cong TranDepartment of Histology, Embryology and Genetics, Pham Ngoc Thach University of Medicine, Ho Chi Minh City 70000, Vietnam.ORCID 0000-0001-5722-8581
Gianna DipalmaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70126 Bari, Italy.ORCID 0000-0002-5947-8987
Angelica BiancoExperimental Zooprophylactic Institute of Puglia and Basilicata, 71121 Foggia, Italy.
Emilio Maria SerlengaHematology Department, Blood Transfusion Unit, SS Annunnziata Hospital, 74100 Taranto, Italy.
Sergey Khachatur AityanMultidisciplinary Research Center, Lincoln University, Oakland, CA 94612, USA.
Valentina PierangeliNEFLT NHS Foundation Trust, Rainham RM13 8EU, UK.
Kieu Cao Diem NguyenDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70126 Bari, Italy.
Francesco InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70126 Bari, Italy.ORCID 0000-0003-3797-5883
Diego TomassoneFoundation of Physics Research Center, 87053 Celico, Italy.ORCID 0000-0001-5161-5417
Ciro Gargiulo IsaccoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70126 Bari, Italy.
University of Bari Aldo Moro · ITAzienda Ospedaliera S.Giuseppe Moscati · ITIstituto Zooprofilattico Sperimentale della Puglia e della Basilicata · ITLincoln University - California · USOspedale SS. Annunziata · ITPham Ngoc Thach University of Medicine · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many factors may influence the risk of being infected by SARS-CoV-2, the coronavirus responsible for coronavirus disease 2019 (COVID-19). Exposure to the virus cannot explain the variety of an individual's responses to the virus and the high differences of effect that the virus may cause to some. While a person's preexisting condition and their immune defenses have been confirmed to play a major role in the disease progression, there is still much to learn about hosts' genetic makeup towards COVID-19 susceptibility and risk. The host genetic makeup may have direct influence on the grade of predisposition and outcomes of COVID-19. In this study, we aimed to investigate the presence of relevant genetic single nucleotide polymorphisms (SNPs), the peripheral blood level of IL6, vitamin D and arterial blood gas (ABG) markers (pH, oxygen-SpO

Indexed as

arterial blood gas (ABG)carbon dioxide (SpCO2)COVID-19oxygen (SpO2)SARS-CoV-2

Identifiers

PMID36428884
PMCPMC9689844
OpenAlexW4309173381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.