ReviewCancers2022
The Prevalence of Lower Limb and Genital Lymphedema after Prostate Cancer Treatment: A Systematic Review.
Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07607431 (Addressing the Forgotten Sex in Lymphedema Research), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Addressing the Forgotten Sex in Lymphedema Research: Risk Factors, Incidence, and Progression of Lymphedema Among Men With Prostate Cancer. The AWARE Cohort
Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Technology-enhanced compression and AI-integrated lymphedema care: a narrative review.Irish journal of medical science · 2025Review
- Lower extremity lymphedema after pelvic nodal dissection for urologic cancers is associated with metastatic recurrence.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2025Article
- Management of Penile Anatomical Deformity Associated With Lymphedema: A Case Report and Literature Review.Cureus · 2025Article
- Impact of Pelvic Lymph Node Dissection on Early Oncological Outcomes in Intermediate-Risk Prostate Cancer Patients With Node-Negative PSMA PET.The Prostate · 2025Article
- Incidence and predictors of lower extremity lymphedema after postoperative radiotherapy for prostate cancer.Radiation oncology (London, England) · 2025Article
- Review
- Multispectral Fluorescence Imaging as a Tool to Distinguish Pelvic Lymphatic Drainage Patterns During Robot-assisted Lymph Node Dissection in Prostate Cancer.Annals of surgical oncology · 2025Observational
- Prevalence of lymphedema symptoms across cancer diagnoses and association with depression, pain interference and health-related quality of life.Acta oncologica (Stockholm, Sweden) · 2025Article
- Post-operative incidence of lymphedema after RARP with or without extended pelvic lymph node dissection in a cohort study.BJUI compass · 2025Article
- Effectiveness of isometric muscle training combined with manual lymphatic drainage on secondary lower extremity lymphedema following gynecologic cancer surgery.Frontiers in bioengineering and biotechnology · 2025Article
- Incidence of cancer-related lymphoedema: a protocol for a living systematic review with meta-analysis.BMJ open · 2024Article
- A digital and nurse-led support intervention, first year after prostate cancer treatment: a single-arm feasibility study in a Swedish primary care setting.BMC primary care · 2024Article
- Cancer-Related Lymphedema and Psychological Distress.Current psychiatry reports · 2024Review
- The influence of non-cancer-related risk factors on the development of cancer-related lymphedema: a rapid review.Medical oncology (Northwood, London, England) · 2024Review
- The"Overlapping"Lymphaticovenous Anastomosis: an overlapped end-to-end anastomosis supermicrosurgical technique.BMC surgery · 2024Article
- Incidence of lymphedema related to various cancers.Medical oncology (Northwood, London, England) · 2024Review
- Characteristics of lymphoedema, in particular midline lymphoedema, after treatment for prostate cancer: a retrospective study.BMC urology · 2024Article
- Etiology and treatment of cancer-related secondary lymphedema.Clinical & experimental metastasis · 2024Review
- Article
- Penoscrotal elephantiasis: A severe form of genital lymphedema.Urology case reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Background: Secondary lymphedema is a chronic, progressive, and debilitating condition with an important impact on quality of life. Lymphedema is a frequently reported complication in oncological surgery but has not been systematically studied in the setting of prostate cancer. (2) Methods: Pubmed/MEDLINE and Embase were systematically searched to identify articles reporting on lower limb or genital lymphedema after primary treatment (surgery of radiation therapy) of the prostate and the pelvic lymph nodes in men with prostate cancer. Primary outcome was the prevalence of lower limb and genital lymphedema. (3) Results: Eighteen articles were eligible for qualitative synthesis. Risk of bias was high in all included studies, with only one study providing a prespecified definition of secondary lymphedema. Eleven studies report the prevalence of lower limb (0-14%) and genital (0-1%) lymphedema after radical prostatectomy with pelvic lymph node dissection (PLND) Seven studies report a low prevalence of lower limb (0-9%) and genital (0-8%) lymphedema after irradiation of the pelvic lymph nodes. However, in the patient subgroups that underwent pelvic irradiation after staging pelvic lymph node dissections, the prevalence of lower limb (18-29%) and genital (2-22%) lymphedema is substantially elevated. (4) Conclusion: Prostate cancer patients undergoing surgery or irradiation of the pelvic lymph nodes are at risk of developing secondary lymphedema in the lower limbs and the genital region. Patients receiving pelvic radiation after pelvic lymph node dissection have the highest prevalence of lymphedema. The lack of a uniform definition and standardized diagnostic criteria for lower limb and genital lymphedema hampers the accurate estimation of their true prevalence. Future clinicals trials are needed to specifically evaluate secondary lymphedema in patients undergoing prostate cancer treatments, to identify potential risk factors and to determine the impact on quality of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.