Evidence map›Paper›PMID 36428722›Full record

ReviewCancers2022

Cancer Patients and the COVID-19 Vaccines: Considerations and Challenges.

Muna Almasri, Khalifa Bshesh, Wafa Khan, Malik Mushannen, Mohammad A Salameh, Ameena Shafiq, Ahamed Lazim Vattoth, Nadine Elkassas, Dalia Zakaria

Abstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Radiation recall dermatitis in cancer patients previously undergoing radiotherapy: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  3. Article
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  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muna AlmasriDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha 24144, Qatar.ORCID 0000-0003-4501-6332
Khalifa BsheshDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha 24144, Qatar.
Wafa KhanDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha 24144, Qatar.
Malik MushannenDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha 24144, Qatar.
Mohammad A SalamehDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha 24144, Qatar.
Ameena ShafiqDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha 24144, Qatar.
Ahamed Lazim VattothDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha 24144, Qatar.
Nadine ElkassasPeninsula Medical School, University of Plymouth, Plymouth PL4 8AA, UK.
Dalia ZakariaDivision of Premedical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha 24144, Qatar.ORCID 0000-0001-9020-0038

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Few guidelines exist for COVID-19 vaccination amongst cancer patients, fostering uncertainty regarding the immunogenicity, safety, and effects of cancer therapies on vaccination, which this review aims to address. A literature review was conducted to include the latest articles covering the immunogenicity and safety of COVID-19 vaccination in patients with solid and hematologic cancers receiving various treatments. Lower seropositivity following vaccination was associated with malignancy (compared to the general population), and hematologic malignancy (compared to solid cancers). Patients receiving active cancer therapy (unspecified), chemotherapy, radiotherapy, and immunosuppressants generally demonstrated lower seropositivity compared to healthy controls; though checkpoint inhibition, endocrine therapy, and cyclin dependent kinase inhibition did not appear to affect seropositivity. Vaccination appeared safe and well-tolerated in patients with current or past cancer and those undergoing treatment. Adverse events were comparable to the general population, but inflammatory lymphadenopathy following vaccination was commonly reported and may be mistaken for malignant etiology. Additionally, radiation recall phenomenon was sporadically reported in patients who had received radiotherapy. Overall, while seropositivity rates were decreased, cancer patients showed capacity to generate safe and effective immune responses to COVID-19 vaccination, thus vaccination should be encouraged and hesitancy should be addressed in this population.

Indexed as

cancercancer therapiesCOVID-19immunogenicitysafetyvaccinationvaccine hesitancy

Identifiers

PMID36428722
PMCPMC9688380

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.