Evidence map›Paper›PMID 36428679›Full record

ArticleCancers2022

Is Regular Radiographic Upper Urinary Tract Imaging for Surveillance of Non-Muscle Invasive Bladder Cancer Justified?

Uwe Bieri, Benedikt Kranzbühler, Burkhardt Seifert, Birgit Maria Helmchen, Alexander Gu, Basil Kaufmann, Dejan Lavrek, Thomas Scherer, Marian S Wettstein, Cédric Poyet and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Uwe BieriDepartment of Urology, University Hospital Zürich, University of Zürich, 8091 Zürich, Switzerland.ORCID 0000-0002-7339-1458
Benedikt KranzbühlerDepartment of Urology, University Hospital Zürich, University of Zürich, 8091 Zürich, Switzerland.
Burkhardt SeifertEpidemiology, Biostatistics and Prevention Institute, University of Zürich, 8006 Zürich, Switzerland.ORCID 0000-0002-5829-2478
Birgit Maria HelmchenDepartment of Pathology, and Molecular Pathology, University Hospital of Zurich, University of Zurich, 8091 Zürich, Switzerland.
Alexander GuDepartment of Urology, University Hospital Zürich, University of Zürich, 8091 Zürich, Switzerland.ORCID 0000-0002-5859-0483
Basil KaufmannDepartment of Urology, University Hospital Zürich, University of Zürich, 8091 Zürich, Switzerland.ORCID 0000-0001-6965-449X
Dejan LavrekDepartment of Urology, University Hospital Zürich, University of Zürich, 8091 Zürich, Switzerland.
Thomas SchererDepartment of Urology, University Hospital Zürich, University of Zürich, 8091 Zürich, Switzerland.
Marian S WettsteinDepartment of Urology, University Hospital Zürich, University of Zürich, 8091 Zürich, Switzerland.
Cédric PoyetDepartment of Urology, University Hospital Zürich, University of Zürich, 8091 Zürich, Switzerland.
Thomas HermannsDepartment of Urology, University Hospital Zürich, University of Zürich, 8091 Zürich, Switzerland.
University of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with non-muscle invasive (NMI) urothelial bladder cancer (BC) are at increased risk for the development of a secondary upper-urinary-tract urothelial carcinoma (UTUC). We aimed to assess the usefulness of routine upper-tract imaging surveillance during NMIBC follow-up in a patient cohort of a tertiary academic center. All routine upper-tract-imaging scans using computerized tomography urography (CTU) between 2003 and 2016 were assessed for UTUC detection. A total of 315 patients were analyzed. Initial tumor stage was Ta in 207 patients (65.7%), T1 in 98 patients (31.1%) and pure CIS in 10 patients (3.2%). A total of 149 (47.3%) presented with low-grade (LG), and 166 (52.7%) with high-grade (HG) disease. Median follow-up was 48 months (IQR: 55). Four patients (1.2%) were diagnosed with UTUC during follow-up. All four patients presented with initial Ta HG BC. Two of the patients (50%) were diagnosed by routine upper tract imaging. The other two patients were diagnosed after development of symptoms. The 5- and 10-year UTUC-free survival was 98.5% (standard error (SE) 0.9) and 97.6% (SE 1.3), respectively. UTUCs were detected exclusively in patients with initial HG disease, indicating that upper-tract surveillance might only be necessary in these patients.

Indexed as

diagnostic imagingsurveillanceupper-urinary-tract urothelial cancerurologic neoplasms

Identifiers

PMID36428679
PMCPMC9688179
OpenAlexW4309215237

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.