Evidence map›Paper›PMID 36428655›Full record

ArticleCancers2022

Development and Validation of Novel Deep-Learning Models Using Multiple Data Types for Lung Cancer Survival.

Jason C Hsu, Phung-Anh Nguyen, Phan Thanh Phuc, Tsai-Chih Lo, Min-Huei Hsu, Min-Shu Hsieh, Nguyen Quoc Khanh Le, Chi-Tsun Cheng, Tzu-Hao Chang, Cheng-Yu Chen

Abstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jason C HsuClinical Data Center, Office of Data Science, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0003-2997-2404
Phung-Anh NguyenClinical Data Center, Office of Data Science, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0002-7436-9041
Phan Thanh PhucInternational Ph.D. Program in Biotech and Healthcare Management, College of Management, Taipei Medical University, Taipei 110, Taiwan.
Tsai-Chih LoGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing Str., Xinyi Dist., Taipei 110, Taiwan.
Min-Huei HsuOffice of Data Science, Taipei Medical University, Taipei 110, Taiwan.
Min-Shu HsiehDepartment of Pathology, National Taiwan University Hospital, Taipei 100, Taiwan.
Nguyen Quoc Khanh LeProfessional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0003-4896-7926
Chi-Tsun ChengResearch Center of Health Care Industry Data Science, College of Management, Taipei Medical University, Taipei 110, Taiwan.
Tzu-Hao ChangClinical Big Data Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0001-7011-3754
Cheng-Yu ChenResearch Center for Artificial Intelligence in Medicine, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0003-0428-4373

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A well-established lung-cancer-survival-prediction model that relies on multiple data types, multiple novel machine-learning algorithms, and external testing is absent in the literature. This study aims to address this gap and determine the critical factors of lung cancer survival. We selected non-small-cell lung cancer patients from a retrospective dataset of the Taipei Medical University Clinical Research Database and Taiwan Cancer Registry between January 2008 and December 2018. All patients were monitored from the index date of cancer diagnosis until the event of death. Variables, including demographics, comorbidities, medications, laboratories, and patient gene tests, were used. Nine machine-learning algorithms with various modes were used. The performance of the algorithms was measured by the area under the receiver operating characteristic curve (AUC). In total, 3714 patients were included. The best performance of the artificial neural network (ANN) model was achieved when integrating all variables with the AUC, accuracy, precision, recall, and F1-score of 0.89, 0.82, 0.91, 0.75, and 0.65, respectively. The most important features were cancer stage, cancer size, age of diagnosis, smoking, drinking status, EGFR gene, and body mass index. Overall, the ANN model improved predictive performance when integrating different data types.

Indexed as

artificial intelligencelung cancermachine learningprediction modelsreal-world datasurvival

Identifiers

PMID36428655
PMCPMC9688689

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.