Evidence map›Paper›PMID 36428640›Full record

ArticleCancers2022

COVID-19 Vaccination Campaign in Cancer Patients and Healthcare Workers-Results from a French Prospective Multicenter Cohort (PAPESCO-19).

Valérie Seegers, Guillaume Rousseau, Ke Zhou, Audrey Blanc-Lapierre, Frédéric Bigot, Hakim Mahammedi, Aurélien Lambert, Camille Moreau-Bachelard, Mario Campone, Thierry Conroy and 4 more

Abstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Valérie SeegersDepartment of Biostatistics, Institut de Cancérologie de l'Ouest (ICO), 44805 Saint-Herblain, France.ORCID 0000-0003-1404-0292
Guillaume RousseauDepartment of Biopathology, Institut de Cancérologie de l'Ouest (ICO), 49055 Angers, France.ORCID 0000-0002-0621-1621
Ke ZhouDepartment of Human and Social Sciences, Institut de Cancérologie de l'Ouest (ICO), 44805 Saint-Herblain, France.
Audrey Blanc-LapierreDepartment of Biostatistics, Institut de Cancérologie de l'Ouest (ICO), 44805 Saint-Herblain, France.
Frédéric BigotDepartment of Medical Oncology, Institut de Cancérologie de l'Ouest (ICO), 49055 Angers, France.
Hakim MahammediDepartment of Medical Oncology, Centre Jean Perrin, 63011 Clermont-Ferrand, France.
Aurélien LambertDepartment of Medical Oncology, Institut de Cancérologie de Lorraine, 54511 Vandoeuvre-lès Nancy, France.ORCID 0000-0001-9990-1201
Camille Moreau-BachelardDepartment of Medical Oncology, Institut de Cancérologie de l'Ouest (ICO), 44805 Saint-Herblain, France.ORCID 0000-0002-4289-8483
Mario CamponeDepartment of Medical Oncology, Institut de Cancérologie de l'Ouest (ICO), 44805 Saint-Herblain, France.
Thierry ConroyDepartment of Medical Oncology, Institut de Cancérologie de Lorraine, 54511 Vandoeuvre-lès Nancy, France.ORCID 0000-0001-7548-284X
Frédérique Penault-LlorcaCentre Jean Perrin, Department of Biopathology and INSERM U1240, Université Clermont Auvergne, 63011 Clermont-Ferrand, France.
Michèle Boisdron-CelleDepartment of Biopathology, Institut de Cancérologie de l'Ouest (ICO), 49055 Angers, France.
Martine BellangerDepartment of Human and Social Sciences, Institut de Cancérologie de l'Ouest (ICO), 44805 Saint-Herblain, France.ORCID 0000-0002-1892-8961
Jean-Luc RaoulDepartment of Clinical Research, Institut de Cancérologie de l'Ouest (ICO), 44800 Saint-Herblain, France.ORCID 0000-0001-6305-8953

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this prospective, real-life cohort study, we followed 523 cancer patients (CP) and 579 healthcare workers (HCW) from two cancer centers to evaluate the biological and clinical results of the COVID-19 vaccination campaign. Seventy percent of the CP and 90% of the HCW received an mRNA vaccine or the AZD1222 vaccine. Seropositivity was high after the first vaccine among HCW and poor among CP. The second dose resulted in almost 100% seropositivity in both cohorts. Antibody response was higher after the second injection than the first in both populations. Despite at least two doses, 8 CP (1.5%) and 14 HCW (2.4%) were infected, corresponding either to a weak level of antibody or a new strain of virus (particularly the Omicron variant of concern). Sixteen CP and three HCW were hospitalized but none of them died from COVID-19. To conclude, this study showed that two doses of COVID-19 vaccines were crucially necessary to attain sufficient seropositivity. However, the post-vaccination antibody level declines in individuals from the two cohorts and could not totally prevent new SARS-CoV-2 infections.

Indexed as

cancer patientsCOVID-19COVID-19 vaccineFranceheath care workersneutralizing antibodyserological tests

Identifiers

PMID36428640
PMCPMC9688516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.