Evidence map›Paper›PMID 36428621›Full record

ArticleCancers2022

Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey.

Chiara Cattaneo, Jon Salmanton-García, Francesco Marchesi, Shaimaa El-Ashwah, Federico Itri, Barbora Weinbergerová, Maria Gomes Da Silva, Michelina Dargenio, Julio Dávila-Valls, Sonia Martín-Pérez and 66 more

Abstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

76 authors.

Chiara CattaneoHematology Unit, ASST-Spedali Civili, 25123 Brescia, Italy.ORCID 0000-0003-0031-3237
Jon Salmanton-GarcíaUniversity of Cologne, Faculty of Medicine, University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany.ORCID 0000-0002-6766-8297
Francesco MarchesiHematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.ORCID 0000-0001-6353-2272
Shaimaa El-AshwahOncology Center, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0003-2210-1534
Federico ItriSan Luigi Gonzaga Hospital, 10043 Orbassano, Italy.ORCID 0000-0002-3532-5281
Barbora WeinbergerováMasaryk University and University Hospital Brno-Department of Internal Medicine, Hematology and Oncology, 62500 Brno, Czech Republic.
Maria Gomes Da SilvaPortuguese Institute of Oncology, 1099-023 Lisbon, Portugal.ORCID 0000-0002-6993-2450
Michelina DargenioHematology and Stem Cell Transplan Unit, Vito Fazzi, 73100 Lecce, Italy.
Julio Dávila-VallsHospital Nuestra Señora de Sonsoles, 05004 Ávila, Spain.ORCID 0000-0002-5185-2073
Sonia Martín-PérezHospital Nuestra Señora de Sonsoles, 05004 Ávila, Spain.
Francesca FarinaIRCCS Ospedale San Raffaele, 20132 Milan, Italy.ORCID 0000-0002-5124-6970
Jaap Van DoesumUniversity Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Toni ValkovićUniversity Hospital Centre Rijeka, 51000 Rijeka, Croatia.
Caroline BessonCentre Hospitalier de Versailles, Le Chesnay, Université Paris-Saclay, UVSQ, Inserm, Équipe "Exposome et Hérédité", CESP, 94800 Villejuif, France.ORCID 0000-0003-4364-7173
Christian Bjørn PoulsenZealand University Hospital, 4000 Roskilde, Denmark.ORCID 0000-0001-9785-1378
Alberto López-GarcíaFundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, 28040 Madrid, Spain.ORCID 0000-0002-5354-5261
Pavel ŽákUniversity Hospital Hradec Králové, 50005 Hradec Králové, Czech Republic.
Martin SchönleinDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0002-1010-0975
Klára PiukovicsDepartment of Internal Medicine, South Division, Faculty of Medicine University of Szeged, 6720 Szeged, Hungary.
Ozren JaksicUniversity Hospital Dubrava, 10000 Zagreb, Croatia.
Alba CabirtaDepartment of Hematology, Vall d'Hebron Hospital Universitari, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, 08193 Barcelona, Spain.ORCID 0000-0001-7198-8894
Natasha AliAga Khan University, 74000 Karachi, Pakistan.ORCID 0000-0003-4990-330X
Uluhan SiliDepartment of Infectious Diseases and Clinical Microbiology, School of Medicine, Marmara University, 34854 Istanbul, Turkey.ORCID 0000-0002-9939-9298
Nicola FracchiollaHematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0002-8982-8079
Giulia DragonettiHematology Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, 00168 Rome, Italy.ORCID 0000-0003-1775-6333
Tatjana Adžić-VukičevićCOVID Hospital "Batajnica", 11000 Belgrade, Serbia.
Monia MarchettiAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.ORCID 0000-0001-7615-0572
Marina MachadoClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain.
Andreas GlenthøjDepartment of Hematology, Copenhagen University Hospital-Rigshospitalet, DK-2100 Copenhagen, Denmark.
Olimpia FinizioUOC Hematology, AORN Cardarelli, 80131 Naples, Italy.
Fatih DemirkanDokuz Eylul University, Division of Hematology, 35340 Izmir, Turkey.
Ola BlennowDepartment of Infectious Diseases, Karolinska University Hospital, 17176 Stockholm, Sweden.
Maria Chiara TisiOspedale San Bortolo, 36100 Vicenza, Italy.
Ali S OmraniCommunicable Disease Center, Hamad Medical Corporation, Doha 3050, Qatar.ORCID 0000-0001-5309-6358
Milan NavrátilUniversity Hospital Ostrava, 70852 Ostrava, Czech Republic.ORCID 0000-0002-2067-1253
Zdeněk RáčilInstitute of Hematology and Blood Transfusion, 12800 Prague, Czech Republic.
Jan NovákDepartment of Hematology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, 12808 Prague, Czech Republic.
Gabriele MaglianoASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy.ORCID 0000-0002-9129-1530
Moraima JiménezDepartment of Hematology, University Hospital Vall d'Hebron, Experimental Hematology, 08035 Barcelona, Spain.
Carolina Garcia-VidalDepartment of Infectious Diseases, Hospital Clinic de Barcelona, University of Barcelona, IDIBAPS, 08035 Barcelona, Spain.
Nurettin ErbenDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Eskisehir Osmangazi University, 26040 Eskisehir, Turkey.
Maria Ilaria Del PrincipeHematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.
Caterina BuquicchioEmatologia Con Trapianto, Ospedale Dimiccoli Barletta, 70051 Barletta, Italy.
Rui BergantimCentro Hospitalar e Universitário São João, 4200-319 Porto, Portugal.ORCID 0000-0002-7811-9509
Josip BatinićUniversity Hospital Centre Zagreb, 10000 Zagreb, Croatia.
Murtadha Al-KhaboriSultan Qaboos University Hospital, Muscat 123, Oman.ORCID 0000-0002-2937-8838
Luisa VergaAzienda Ospedaliera San Gerardo-Monza, 20900 Monza, Italy.
Tomáš SzotkowskiUniversity Hospital Olomouc, 77900 Olomouc, Czech Republic.
Michail SamarkosLaikon Hospital, 11527 Athens, Greece.ORCID 0000-0001-9630-9712
Irati Ormazabal-VélezHospital Universitario de Navarra, 31008 Iruña-Pamplona, Spain.ORCID 0000-0003-1141-5546
Stef MeersAZ KLINA, 2930 Brasschaat, Belgium.
Johan MaertensKU Leuven, 3000 Leuven, Belgium.ORCID 0000-0003-4257-5980
László Imre PinczésDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0003-0453-1709
Martin HoeniglDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-1653-2824
Ľuboš DrgoňaDepartment of Oncohematology, Comenius University and National Cancer Institute, 81499 Bratislava, Slovakia.
Annarosa CuccaroHematology Unit, Center for Translational Medicine, Azienda USL Toscana NordOvest, 55100 Livorno, Italy.ORCID 0000-0002-0237-1839
Yavuz M BilginDepartment of Internal Medicine, ADRZ, 4462 RA Goes, The Netherlands.
Avinash AujayebNorthumbria Healthcare, Newcastle NE29 8NH, UK.ORCID 0000-0002-0859-5550
Laman RahimliUniversity of Cologne, Faculty of Medicine, University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany.
Stefanie GräfeUniversity of Cologne, Faculty of Medicine, University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany.
Mariarita SciumèHematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0001-7958-4966
Miloš MladenovićCOVID Hospital "Batajnica", 11000 Belgrade, Serbia.
Gökçe Melis ÇolakDepartment of Infectious Diseases and Clinical Microbiology, School of Medicine, Marmara University, 34854 Istanbul, Turkey.ORCID 0000-0001-9065-374X
Maria Vittoria SacchiAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
Anna NordlanderDepartment of Infectious Diseases, Karolinska University Hospital, 17176 Stockholm, Sweden.
Caroline Berg VenemyrDepartment of Hematology, Copenhagen University Hospital-Rigshospitalet, DK-2100 Copenhagen, Denmark.
Michaela HanákováInstitute of Hematology and Blood Transfusion, 12800 Prague, Czech Republic.
Nicole García-PoutónVall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, 08035 Barcelona, Spain.
Ziad EmarahOncology Center, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0003-0622-2598
Giovanni Paolo Maria ZambrottaSultan Qaboos University Hospital, Muscat 123, Oman.ORCID 0000-0002-8612-2994
Raquel Nunes RodriguesPortuguese Institute of Oncology, 1099-023 Lisbon, Portugal.
Raul CordobaFundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, 28040 Madrid, Spain.
Gustavo-Adolfo MéndezHospital Escuela de Agudos Dr. Ramón Madariaga, Posadas 3736, Argentina.
Monika M BiernatDepartment of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, 50-425 Wroclaw, Poland.
Oliver A CornelyUniversity of Cologne, Faculty of Medicine, University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany.ORCID 0000-0001-9599-3137
Livio PaganoHematology Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, 00168 Rome, Italy.ORCID 0000-0001-8287-928X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The outcome of patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 is unknown and there are no specific treatment guidelines. Methods: We describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Results: Acute leukaemia and lymphoma were the most frequent HM (35.8% and 35.1%, respectively). Overall, 343 (76.2%) patients received treatment for HM, which was delayed for longer than one month since diagnosis in 57 (16.6%). An overall response rate was observed in 140 (40.8%) patients after the first line of treatment. After a median follow-up of 35 days, overall mortality was 177/450 (39.3%); 30-day mortality was significantly higher in patients not receiving HM treatment (42.1%) than in those receiving treatment (27.4%, p = 0.004), either before and/or after COVID-19, or compared to patients receiving HM treatment at least after COVID-19 (15.2%, p < 0.001). Age, severe/critical COVID-19, ≥2 comorbidities, and lack of HM treatment were independent risk factors for mortality, whereas a lymphocyte count >500/mcl at COVID-19 onset was protective. Conclusions: HM treatment should be delivered as soon as possible for patients with simultaneous diagnosis of COVID-19 and HM requiring immediate therapy.

Indexed as

COVID-19haematological malignancy onsetoutcomeprognostic factorstreatment

Identifiers

PMID36428621
PMCPMC9688278

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