Evidence map›Paper›PMID 36428590›Full record

ArticleCancers2022

Feasibility Study on the Radiation Dose by Radioactive Magnetic Core-Shell Nanoparticles for Open-Source Brachytherapy.

Rogier van Oossanen, Jeremy Godart, Jeremy M C Brown, Alexandra Maier, Jean-Philippe Pignol, Antonia G Denkova, Kristina Djanashvili, Gerard C van Rhoon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rogier van OossanenDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, 3015GD Rotterdam, The Netherlands.ORCID 0000-0002-7010-947X
Jeremy GodartDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, 3015GD Rotterdam, The Netherlands.
Jeremy M C BrownDepartment of Radiation Science and Technology, TU Delft, 2629JB Delft, The Netherlands.
Alexandra MaierDepartment of Radiation Science and Technology, TU Delft, 2629JB Delft, The Netherlands.
Jean-Philippe PignolDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, 3015GD Rotterdam, The Netherlands.
Antonia G DenkovaDepartment of Radiation Science and Technology, TU Delft, 2629JB Delft, The Netherlands.
Kristina DjanashviliDepartment of Radiation Science and Technology, TU Delft, 2629JB Delft, The Netherlands.ORCID 0000-0003-1511-015X
Gerard C van RhoonDepartment of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, 3015GD Rotterdam, The Netherlands.ORCID 0000-0002-7365-5783

Funding

Dutch Research Council 16238
6 · The paper itself

Abstract

backgroundTreatment of early-stage breast cancer currently includes surgical removal of the tumor and (partial) breast irradiation of the tumor site performed at fractionated dose. Although highly effective, this treatment is exhaustive for both patient and clinic. In this study, the theoretical potential of an alternative treatment combining thermal ablation with low dose rate (LDR) brachytherapy using radioactive magnetic nanoparticles (RMNPs) containing 103-palladium was researched.

methodsThe radiation dose characteristics and emission spectra of a single RMNP were calculated, and dose distributions of a commercial brachytherapy seed and an RMNP brachytherapy seed were simulated using Geant4 Monte Carlo toolkit.

resultsIt was found that the RMNP seeds deliver a therapeutic dose similar to currently used commercial seed, while the dose distribution shows a spherical fall off compared to the more inhomogeneous dose distribution of the commercial seed. Changes in shell thickness only changed the dose profile between 2 × 10

conclusionThe dose distribution of the RMNP seed is comparable with current commercial brachytherapy seeds, while anisotropy of the dose distribution is reduced. Because this reduces the dependency of the dose distribution on the orientation of the seed, their surgical placement is easier. This supports the feasibility of the clinical application of the proposed novel treatment modality.

Indexed as

brachytherapydual-function nanoparticlesmagnetic hyperthermiamagnetic nanoparticlesMonte Carlo simulationsthermal ablation

Identifiers

PMID36428590
PMCPMC9688633

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.