Evidence map›Paper›PMID 36428571›Full record

ArticleCancers2022

Expression of Intermediate Filaments in the Developing Testis and Testicular Germ Cell Cancer.

Maria E Camacho-Moll, Leendert H J Looijenga, Roland Donat, Chitranjan J Shukla, Anne Jørgensen, Rod T Mitchell

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 4 countries.

Maria E Camacho-MollDepartment of Molecular Biology, Northeast Centre for Biomedical Research, Mexican Institute for Social Security, 2 de abril 501, Esq. San Luis Potosi, Col. Independencia, Monterrey C.P. 64720, Nuevo León, Mexico.ORCID 0000-0003-4950-6574
Leendert H J LooijengaPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands.ORCID 0000-0002-8146-1911
Roland DonatDepartment of Urology, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK.
Chitranjan J ShuklaDepartment of Urology, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK.
Anne JørgensenDepartment of Growth and Reproduction, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Rod T MitchellMRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK.ORCID 0000-0003-4650-3765
Western General Hospital · GBMexican Social Security Institute · MXMRC Centre for Reproductive Health · GBPrincess Máxima Center · NLRigshospitalet · DK

Funding

Medical Research Council MR/N022556/1Medical Research Council MR/S017151/1Wellcome TrustWellcome Trust 098522
6 · The paper itself

Abstract

Cytokeratin and desmin expression have been associated with Sertoli cell maturity and the development of testicular germ cell cancer (TGCC). Thus, the present study aimed to characterize the expression of these intermediate filaments in normal testis development and TGCC. Cytokeratin and desmin were determined by immunohistochemistry and immunofluorescence in human fetal, and adult testis and tissue from patients with pre-invasive germ cell neoplasia in-situ (GCNIS) or invasive TGCC. Desmin was expressed in Sertoli cells of the human fetal testis, and the proportion of desmin expressing Sertoli cells was significantly reduced in the second trimester, compared with the first trimester (31.14% vs. 6.74%,

Indexed as

cytokeratindesminGCNIShuman testisintermediate filamentsSertoli cellsTGCC

Identifiers

PMID36428571
PMCPMC9688874
OpenAlexW4308522401

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.