Evidence map›Paper›PMID 36428307›Full record

ArticleAnimals : an open access journal from MDPI2022

Pathogenicity and Transmissibility of Clade 2.3.4.4h H5N6 Avian Influenza Viruses in Mammals.

Cheng Zhang, Huan Cui, Chunmao Zhang, Kui Zhao, Yunyi Kong, Ligong Chen, Shishan Dong, Zhaoliang Chen, Jie Pu, Lei Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cheng ZhangCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071000, China.ORCID 0000-0003-3049-1587
Huan CuiChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Chunmao ZhangChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Kui ZhaoCollege of Animal Medicine, Jilin University, Changchun 130062, China.
Yunyi KongChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Ligong ChenCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071000, China.
Shishan DongCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071000, China.
Zhaoliang ChenCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071000, China.
Jie PuChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Lei ZhangChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Zhendong GuoChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Juxiang LiuCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071000, China.

Funding

Hebei Industrial Technology System HBCT2018150210Key Research Projects in Hebei Province 18227517D
6 · The paper itself

Abstract

Avian influenza viruses (AIVs) have the potential for cross-species transmission and pandemics. In recent years, clade 2.3.4.4 H5N6 AIVs are prevalent in domestic poultry, posing a threat to the domestic poultry industry and public health. In this study, two strains of H5N6 AIVs were isolated from chickens in Hebei, China, in 2019: A/chicken/Hebei/HB1907/2019(H5N6) and A/chicken/Hebei/HB1905/2019(H5N6). Phylogenetic analysis showed that both viral HA genes clustered in the 2.3.4.4h clade. Receptor binding analysis showed that the HB1905 strain preferentially binds to α-2,3-linked sialic acid (SA) receptors, while the HB1907 strain preferentially binds to α-2,3- and α-2,6-linked sialic acid (SA) receptors. During early infection, the HB1907 strain is highly replicable in MDCK cells, more so than the HB1905 strain. Pathogenicity assays in mice showed that both viruses could replicate in the lungs without prior adaptation, with HB1907 being more highly pathogenic in mice than the HB1905 strain. Significantly, both the HB1905 and HB1907 strains can be transmitted through direct contact among guinea pigs, but the transmission efficiency of the HB1907 strain through contact between guinea pigs is much greater than that of the HB1905 strain. These results strengthen the need for ongoing surveillance and early warning of H5N6 AIVs in poultry.

Indexed as

avian influenzachickensH5N6 subtypepathogenicitytransmissibility

Identifiers

PMID36428307
PMCPMC9686590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.