ArticleAnimals : an open access journal from MDPI2022
Glycine Alleviated Intestinal Injury by Inhibiting Ferroptosis in Piglets Challenged with Diquat.
Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Glycine Alleviates HMolecular neurobiology · 2026Article
- Glycine alleviates ovarian granulosa cell ferroptosis induced by ERα-mediated internalization of polystyrene microplastics.Communications biology · 2026Article
- Ferroptosis in veterinary medicine: mechanisms, therapies, and unmet challenges.The veterinary quarterly · 2025Review
- Molecular mechanisms in diquat-induced organs injury：insights into cell signaling and potential therapeutic agents.Cell biology and toxicology · 2025Review
- [Inhibition of ferroptosis alleviates acute kidney injury caused by diquat in zebrafish].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- The multifaceted role of ferroptosis in infection and injury and its nutritional regulation in pigs.Journal of animal science and biotechnology · 2025Review
- Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies.Frontiers in pharmacology · 2025Review
- Article
- Vascular endothelium, a promising target for effectively treating fulminant diquat intoxication?World journal of clinical cases · 2024Article
- Amino acids in piglet diarrhea: Effects, mechanisms and insights.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Accurate models and nutritional strategies for specific oxidative stress factors: Does the dose matter in swine production?Journal of animal science and biotechnology · 2024Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this research was to examine the impact of glycine on intestinal injury caused by oxidative stress in piglets. A 2 × 2 factorial experiment with diets (basic diet vs. 1% glycine diet) and oxidative stress (saline vs. diquat) was conducted on 32 weanling piglets. On day 21, all piglets received an injection of either saline or diquat. After 7 days, all pigs were slaughtered and intestinal samples were collected. Dietary glycine supplementation improved intestinal mucosal morphology, increased the activities of disaccharidases and enhanced intestinal mucosal antioxidant capacity, while regulating the expression of ferroptosis mediators in the piglets under oxidative stress. These findings suggested that dietary glycine supplementation improved the morphology and function of the intestinal mucosa, which was involved in regulating antioxidant capacity and ferroptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.