ArticleThe British journal of ophthalmology2023
Optical coherence tomography angiography for the characterisation of retinal microvasculature alterations in pregnant patients with anaemia: a nested case‒control study.
Article in The British journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Characteristics of optical coherence tomography in patients with iron deficiency anemia : a systematic review and meta-analysis.BMC ophthalmology · 2024Pooled it
- Noninvasive early prediction of preeclampsia in pregnancy using retinal vascular features.NPJ digital medicine · 2025Article
- OCT Angiography of Type 1 Macular Neovascularization in AMD: A Morphometric Evaluation.Translational vision science & technology · 2025Observational
- Quantitative detection of macular microvascular abnormalities identified by optical coherence tomography angiography in different hematological diseases.Scientific reports · 2024Article
- Diagnosing Systemic Disorders with AI Algorithms Based on Ocular Images.Healthcare (Basel, Switzerland) · 2023Review
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Authors and funding
25 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo characterise retinal microvascular alterations in the eyes of pregnant patients with anaemia (PA) and to compare the alterations with those in healthy controls (HC) using optical coherence tomography angiography (OCTA).
methodsThis nested case‒control study included singleton PA and HC from the Eye Health in Pregnancy Study. Fovea avascular zone (FAZ) metrics, perfusion density (PD) in the superficial capillary plexus, deep capillary plexus and flow deficit (FD) density in the choriocapillaris (CC) were quantified using FIJI software. Linear regressions were conducted to evaluate the differences in OCTA metrics between PA and HC. Subgroup analyses were performed based on comparisons between PA diagnosed in the early or late trimester and HC.
resultsIn total, 99 eyes of 99 PA and 184 eyes of 184 HC were analysed. PA had a significantly reduced FAZ perimeter (
conclusionIt was found that anaemia during pregnancy was associated with macular microvascular abnormalities, which differed in PA as pregnancy progressed. The results suggest that quantitative OCTA metrics may be useful for risk evaluation before clinical diagnosis. TRIAL REGISTRATION NUMBERS: 2021KYPJ098 and ChiCTR2100049850.
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