SynthesisNeuroImage2022
Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task.
Synthesis in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 45 citations in OpenAlex.
- Subacute effects of ketamine on neural correlates of reward processing.Translational psychiatry · 2026Trial
- Brain functional basis of the association between positive expectation and acupuncture efficacy in knee osteoarthritis.Brain imaging and behavior · 2026Trial
- Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour.Nature communications · 2025Trial
- Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism.Nature communications · 2026Article
- Distinct neural responses to punishment anticipation in violent and non-violent individuals with schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Common Neural Deficits in Social and Monetary Reinforcement Learning in Schizophrenia.Schizophrenia bulletin · 2026Article
- Anterior insula reactivity to loss moderates the association between trait impulsivity and future suicidal ideation in adolescents.Developmental cognitive neuroscience · 2026Article
- Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A mindfulness-based intervention to reduce altered brain reward function in cannabis use disorder: a double-blind, active and passive, randomised controlled fMRI trial.Psychopharmacology · 2026Article
- Reward-Related Brain Function as an Endophenotype in the Mood-Psychosis Spectrum.Biological psychiatry global open science · 2026Article
- Persistent appetitive memory in problematic pornography users.Journal of behavioral addictions · 2026Article
- Mesocorticolimbic circuitry in episodic migraine: reward- and punishment-related responses and resting-state connectivity.The journal of headache and pain · 2026Article
- Blunted Ventral Striatal Reactivity to Social Reward Is Associated with More Severe Motivation and Pleasure Deficits in Psychosis.Schizophrenia bulletin · 2025Article
- Neural reward processing among children with conduct disorder and mild traumatic brain injury in the ABCD study.Psychological medicine · 2025Article
- Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Investigating Neural Reward Sensitivity in the School Grade Incentive Delay Task and Its Relation to Academic Buoyancy.Behavioral sciences (Basel, Switzerland) · 2025Article
- Neural Correlates of Reward Processing: Impact of Individual Differences in Preference for Prosocial Interactions.Brain and behavior · 2025Article
- Anhedonia relates to reduced striatal reward anticipation in depression but not in schizophrenia or bipolar disorder: A transdiagnostic study.Cognitive, affective & behavioral neuroscience · 2025Article
- Neural mechanisms of reward processing in preadolescent irritability: Insights from the ABCD study.Journal of affective disorders · 2025Article
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Reward and punishment motivate decision making and behavioral changes. Numerous studies have examined regional activities during anticipation and outcome of win and loss in the monetary incentive delay task (MIDT). However, the great majority of studies reported findings of anticipation or outcome and of win or loss alone. It remains unclear how the neural correlates share and differentiate amongst these processes. We conducted an Activation Likelihood Estimation meta-analysis of 81 studies of the MIDT (5,864 subjects), including 24 published since the most recent meta-analysis, to identify and, with conjunction and subtraction, contrast regional responses to win anticipation, loss anticipation, win outcome, and loss outcome. Win and loss anticipation engaged a shared network of bilateral anterior insula (AI), striatum, thalamus, supplementary motor area (SMA), and precentral gyrus. Win and loss outcomes did not share regional activities. Win and loss outcome each engaged higher activity in medial orbitofrontal cortex (mOFC) and dorsal anterior cingulate cortex. Bilateral striatum and right occipital cortex responded to both anticipation and outcome of win, and right AI to both phases of loss. Win anticipation vs. outcome engaged higher activity in bilateral AI, striatum, SMA and precentral gyrus and right thalamus, and lower activity in bilateral mOFC and posterior cingulate cortex as well as right inferior frontal and angular gyri. Loss anticipation relative to outcome involved higher activity in bilateral striatum and left AI. These findings collectively suggest shared and distinct regional responses during monetary wins and losses. Delineating the neural correlates of these component processes may facilitate empirical research of motivated behaviors and dysfunctional approach and avoidance in psychopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.