Evidence map›Paper›PMID 36427488›Full record

ArticleClinical biomechanics (Bristol, Avon)2022

Increase in serum nerve growth factor but not intervertebral disc degeneration following whole-body vibration in rats.

Folly M Patterson, Raheleh Miralami, Alicia K Olivier, Kaylin McNulty, John W Wood, R K Prabhu, Lauren B Priddy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Folly M PattersonDepartment of Agricultural and Biological Engineering, Mississippi State University, 130 Creelman Street, Mississippi State, MS, 39762, USA; Center for Advanced Vehicular Systems, Mississippi State University, 200 Research Blvd, Starkville, MS 39759, USA. Electronic address: fdc33@msstate.edu.
Raheleh MiralamiDepartment of Agricultural and Biological Engineering, Mississippi State University, 130 Creelman Street, Mississippi State, MS, 39762, USA; Center for Advanced Vehicular Systems, Mississippi State University, 200 Research Blvd, Starkville, MS 39759, USA. Electronic address: raheleh@cavs.msstate.edu.
Alicia K OlivierDepartment of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, 240 Wise Center Drive, Mississippi State, MS 39762, USA. Electronic address: alicia.olivier@msstate.edu.
Kaylin McNultyDepartment of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, 240 Wise Center Drive, Mississippi State, MS 39762, USA. Electronic address: kaylin.mcnulty@msstate.edu.
John W WoodDepartment of Agricultural and Biological Engineering, Mississippi State University, 130 Creelman Street, Mississippi State, MS, 39762, USA; Center for Advanced Vehicular Systems, Mississippi State University, 200 Research Blvd, Starkville, MS 39759, USA. Electronic address: jwwood@mdanderson.org.
R K PrabhuDepartment of Agricultural and Biological Engineering, Mississippi State University, 130 Creelman Street, Mississippi State, MS, 39762, USA; Center for Advanced Vehicular Systems, Mississippi State University, 200 Research Blvd, Starkville, MS 39759, USA. Electronic address: rprabhu@usra.edu.
Lauren B PriddyDepartment of Agricultural and Biological Engineering, Mississippi State University, 130 Creelman Street, Mississippi State, MS, 39762, USA; Center for Advanced Vehicular Systems, Mississippi State University, 200 Research Blvd, Starkville, MS 39759, USA. Electronic address: lbpriddy@abe.msstate.edu.

Funding

Zinc dependent conformational changes in AdcR and their impact on DNA bindingP20GM103646 · NIGMS · MISSISSIPPI STATE UNIVERSITY · PI NANDURI, BINDU · 2013 to 2022
$21.1M
NIGMS NIH HHS P20 GM103646
6 · The paper itself

Abstract

backgroundLow back pain is a leading cause of disability and is frequently associated with whole-body vibration exposure in industrial workers and military personnel. While the pathophysiological mechanisms by which whole-body vibration causes low back pain have been studied in vivo, there is little data to inform low back pain diagnosis. Using a rat model of repetitive whole-body vibration followed by recovery, our objective was to determine the effects of vibration frequency on hind paw withdrawal threshold, circulating nerve growth factor concentration, and intervertebral disc degeneration.

methodsMale Sprague-Dawley rats were vibrated for 30 min at an 8 Hz or 11 Hz frequency every other day for two weeks and then recovered (no vibration) for one week. Von Frey was used to determine hind paw mechanical sensitivity every two days. Serum nerve growth factor concentration was determined every four days. At the three-week endpoint, intervertebral discs were graded histologically for degeneration.

findingsThe nerve growth factor concentration increased threefold in the 8 Hz group and twofold in the 11 Hz group. The nerve growth factor concentration did not return to baseline by the end of the one-week recovery period for the 8 Hz group. Nerve growth factor serum concentration did not coincide with intervertebral disc degeneration, as no differences in degeneration were observed among groups. Mechanical sensitivity generally decreased over time for all groups, suggesting a habituation (desensitization) effect.

interpretationThis study demonstrates the potential of nerve growth factor as a diagnostic biomarker for low back pain due to whole-body vibration.

Indexed as

Intervertebral Disc DegenerationLow Back PainNerve Growth FactorsVibrationAnimalsMaleRatsRats, Sprague-DawleyNerve Growth FactorsIntervertebral discNerve growth factorPainSpineWhole-body vibration

Identifiers

PMID36427488
PMCPMC9742305

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.