ArticleScience advances2022
An automated DNA computing platform for rapid etiological diagnostics.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Programmable DNA Logic Systems for Applications in Biomedicine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Advances in Machine Learning-Assisted Optical Sensing Arrays for Disease Diagnosis.Biomimetics (Basel, Switzerland) · 2026Review
- Development of a multifunctional nucleic acid response platform utilizing the Cas12a and Cas13a integrated targeting system.Nucleic acids research · 2026Article
- Reset-free DNA logic circuits for real-time input processing and memory.Science advances · 2026Article
- Concept, development and applications of DNA computation.Fundamental research · 2026Review
- Deep convolutional and fully-connected DNA neural networks.Nature communications · 2025Article
- Polymerase-based DNA reactions for molecularly computing cancerous diagnostic valences of multiple miRNAs.Journal of nanobiotechnology · 2025Article
- DNA Molecular Computing with Weighted Signal Amplification for Cancer miRNA Biomarker Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Implementing complex nucleic acid circuits in living cells.Science advances · 2025Article
- High-Speed Sequential DNA Computing Using a Solid-State DNA Origami Register.ACS central science · 2024Article
- Plug-and-play protein biosensors using aptamer-regulated in vitro transcription.Nature communications · 2024Article
- SemiSynBio: A new era for neuromorphic computing.Synthetic and systems biotechnology · 2024Review
- Precise control of transmembrane current via regulating bionic lipid membrane composition.Science advances · 2024Article
- A spatially localized DNA linear classifier for cancer diagnosis.Nature communications · 2024Article
- DNA-based molecular classifiers for the profiling of gene expression signatures.Journal of nanobiotechnology · 2024Article
- A DNA circuit that records molecular events.Science advances · 2024Article
- A signal transmission strategy driven by gap-regulated exonuclease hydrolysis for hierarchical molecular networks.Communications biology · 2024Article
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- Smart DNA sensors-based molecular identification for cancer subtyping.Smart molecules : open access · 2023Review
- Disrupting the infectious disease ecosystem in the digital precision health era innovations and converging emerging technologies.Antimicrobial agents and chemotherapy · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid and accurate classification of the etiology for acute respiratory illness not only helps establish timely therapeutic plans but also prevents inappropriate use of antibiotics. Host gene expression patterns in peripheral blood can discriminate bacterial from viral causes of acute respiratory infection (ARI) but suffer from long turnaround time, as well as high cost resulting from the measurement methods of microarrays and next-generation sequencing. Here, we developed an automated DNA computing-based platform that can implement an in silico trained classification model at the molecular level with seven different mRNA expression patterns for accurate diagnosis of ARI etiology in 4 hours. By integrating sample loading, marker amplification, classifier implementation, and results reporting into one platform, we obtained a diagnostic accuracy of 87% in 80 clinical samples without the aid of computer and laboratory technicians. This platform creates opportunities toward an accurate, rapid, low-cost, and automated diagnosis of disease etiology in emergency departments or point-of-care clinics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.