ArticleThe Plant cell2023
Natural variation in CRABS CLAW contributes to fruit length divergence in cucumber.
Article in The Plant cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
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- StCYP90C1 modulates plant architecture via regulating brassinosteroid biosynthesis in potato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- The Phylogeny of Brassicaceae YABBYs and theInternational journal of molecular sciences · 2026Article
- The Microtubule-Associated Protein CsTON2 Interacts With CsTRM5 and CsSUN to Regulate Fruit Shape Development in Cucumber.Plant biotechnology journal · 2026Article
- Genome-Wide Identification of the YABBY Gene Family in Maize and Its Expression Analysis Under Low Phosphorus and High Nitrogen Stress.Plants (Basel, Switzerland) · 2025Article
- Genetic Mapping of a QTL Controlling Fruit Size in Melon (Plants (Basel, Switzerland) · 2025Article
- The IQ67-domain protein IQD1 regulates fruit shape through complex multiprotein interactions in pepper (Capsicum annuum L.).Plant biotechnology journal · 2025Article
- The development of ideal insertion and deletion (InDel) markers and initial indel map variation in cucumber using re-sequenced data.BMC genomics · 2025Article
- Genome Assembly and Winged Fruit Gene Regulation of Chinese Wingnut: Insights from Genomic and Transcriptomic Analyses.Genomics, proteomics & bioinformatics · 2025Article
- Transcriptomic analysis reveals the crucial role of YABBY genes family in hormonal induced parthenocarpy in Cucumis sativus L.BMC plant biology · 2025Article
- Morphological and molecular mechanisms of floral nectary development in Chinese Jujube.BMC plant biology · 2024Article
- Single nucleotide polymorphisms in SEPALLATA 2 underlie fruit length variation in cucurbits.The Plant cell · 2024Article
- SlCRCa is a key D-class gene controlling ovule fate determination in tomato.Plant biotechnology journal · 2024Article
- Heterotrimeric Gα-subunit regulates flower and fruit development in CLAVATA signaling pathway in cucumber.Horticulture research · 2024Article
- Fine mapping of TFL, a major gene regulating fruit length in snake gourd (Trichosanthes anguina L).BMC plant biology · 2024Article
- A nonsynonymous mutation in BhLS, encoding an acyl-CoA N-acyltransferase leads to fruit and seed size variation in wax gourd (Benincasa hispida).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Heat stress impairs floral meristem termination and fruit development by affecting the BR-SlCRCa cascade in tomato.Plant communications · 2024Article
- Natural variation in BnaA9.NF-YA7 contributes to drought tolerance in Brassica napus L.Nature communications · 2024Article
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fruit length is a key domestication trait that affects crop yield and appearance. Cucumber (Cucumis sativus) fruits vary from 5 to 60 cm in length. Despite the identification of several regulators and multiple quantitative trait loci (QTLs) underlying fruit length, the natural variation, and molecular mechanisms underlying differences in fruit length are poorly understood. Through map-based cloning, we identified a nonsynonymous polymorphism (G to A) in CRABS CLAW (CsCRC) as underlying the major-effect fruit size/shape QTL FS5.2 in cucumber. The short-fruit allele CsCRCA is a rare allele that has only been found in round-fruited semi-wild Xishuangbanna cucumbers. A near-isogenic line (NIL) homozygous for CsCRCA exhibited a 34∼39% reduction in fruit length. Introducing CsCRCG into this NIL rescued the short-fruit phenotype, and knockdown of CsCRCG resulted in shorter fruit and smaller cells. In natural cucumber populations, CsCRCG expression was positively correlated with fruit length. Further, CsCRCG, but not CsCRCA, targets the downstream auxin-responsive protein gene CsARP1 to regulate its expression. Knockout of CsARP1 produced shorter fruit with smaller cells. Hence, our work suggests that CsCRCG positively regulates fruit elongation through transcriptional activation of CsARP1 and thus enhances cell expansion. Using different CsCRC alleles provides a strategy to manipulate fruit length in cucumber breeding.
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