ReviewJournal of cell communication and signaling2023
Cell-cell communications: new insights into targeting efficacy of phytochemical adjuvants on tight junctions and pathophysiology of various malignancies.
Review in Journal of cell communication and signaling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Intestinal and Blood-Brain Barrier Dysfunction in Lupus: Emerging Mechanisms and Modulation by Cinnamon.Molecules (Basel, Switzerland) · 2026Review
- A Multiscale Computational Architecture to Study Signaling Dynamics at Cell-Cell Interfaces.bioRxiv : the preprint server for biology · 2026Article
- Article
- Aberrant Expression of JAM2 Inhibits Invasion and Migration in Lung Adenocarcinoma.Cancer reports (Hoboken, N.J.) · 2025Article
- Impact of oxytosis on the cross-talk of mTORC with mitochondrial proteins in drug-resistant cancer stem cells.Journal of cellular physiology · 2024Review
- ACAT1 promotes proliferation and metastasis of bladder cancer via AKT/GSK3β/c-Myc signaling pathway.Journal of Cancer · 2024Article
- Down-Regulation of Cysteine-Glutamate Antiporter in ALDH1A1 Expressing Oral and Breast Cancer Stem Cells Induced Oxidative Stress-Triggered Ferroptosis.Journal of Cancer · 2024Article
- AqueousFrontiers in pharmacology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is a cellular impairment disorder characterized by the loss of cell cycle regulation leading to aberrant cell proliferation. Cell-cell communication plays a crucial role in cell signaling which is highly disrupted in various malignancies. Tight junctions (TJs) are major proteins that regulate the proper communication, and the dysregulation of TJ proteins makes these tumor cells more aggressive, leading to tumor invasion and metastasis. Hence targeting TJs might be a novel insight towards addressing these highly invasive, metastatic tumors. Due to the prohibitive costs of treatments, side effects, and development of resistance, herbal medications comprising bioactive ingredients have become more popular for various human ailments. Unfortunately, the importance of natural compounds has significantly reduced due to the development of modern synthetic techniques to formulate drugs. However, the pharmaceutical industry that adopts chemistry-based drug development in combination with high throughput synthesis have not resulted in the expected drug productivity. Hence, the focus was shifted back to natural compounds in search of novel drugs with advanced technology to isolate the biologically active compound from the natural ones. The current review delivers the importance of TJ regulation, promoting it through phytochemicals to target malignant tumor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.